کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114856 1084559 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
IGFBPs contribute to survival of pancreatic cancer cells under severely hypoxic conditions
چکیده انگلیسی

Protein synthesis in general is suppressed under hypoxic conditions in both cancer cells and normal cells. In human pancreatic cancer AsPC-1 cells, which are resistant to low oxygen tension, protein synthesis at day 4 under hypoxia (1% O2) was about 20% of that under normoxia. Secretion of some proteins actually increased in spite of a general reduction in protein synthesis; two of these proteins were insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3. Hypoxia also induced transcription of multiple IGFBPs. The IGFBPs contributed to reduced IGF signaling and to the survival of cancer cells under conditions of low oxygen tension.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 268, Issue 1, 8 September 2008, Pages 82–88
نویسندگان
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