کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2114858 1084559 2008 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical significance and regulation of the costimulatory molecule B7-H1 in pancreatic cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Clinical significance and regulation of the costimulatory molecule B7-H1 in pancreatic cancer
چکیده انگلیسی

We investigated the expression pattern and clinical significance of the costimulatory ligands B7-1, B7-2, B7-H1, and B7-DC, and their counter-receptors CTLA-4 and PD-1 in pancreatic cancer. Gene expression of all examined costimulatory molecules was significantly upregulated in pancreatic cancer tissues. B7-1, B7-2, B7-H1, and B7-DC protein was detectable in pancreatic cancer cells. Only the expression of B7-H1 significantly correlated with postoperative survival (p < 0.0001). B7-H1 was inducible in cultured pancreatic cancer cells by IFN-γ and significantly correlated with the level of IFN-γ expression in human pancreatic cancer tissues (Spearman ρ = 0.4536, p = 0.0029). B7-H1 positive tumors showed an increased prevalence of tumor-infiltrating regulatory T cells (Tregs) compared to B7-H1 negative tumors.Among the investigated costimulatory molecules only tumor-associated B7-H1 seems to be of prognostic relevance in pancreatic cancer. B7-H1 might, therefore, be involved in the downregulation of antitumor responses through regulation of Tregs in pancreatic cancer. Our findings also suggest a dual role of IFN-γ in antitumor response. Through induction of B7-H1 in pancreatic cancer cells IFN-γ might contribute to the evasion of antitumor immunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 268, Issue 1, 8 September 2008, Pages 98–109
نویسندگان
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