کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2114939 | 1084564 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Immune gene therapy as a neoadjuvant to surgical excision to control metastatic cancers
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Immune gene therapy as a neoadjuvant to surgical excision to control metastatic cancers Immune gene therapy as a neoadjuvant to surgical excision to control metastatic cancers](/preview/png/2114939.png)
چکیده انگلیسی
We investigated if the range of efficacy of a gene-based immunotherapy of solid tumours against systemic disease could be extended when used as a neoadjuvant to surgery. Hundred percent mice whose subcutaneous tumours were surgically removed 4 days post-electroporation with GM-CSF and B7-1 plasmid were systemically resistance to tumour rechallenge. In mice bearing both subcutaneous and hepatic tumours, neoadjuvant treatment of the primary tumour resulted in significant reduction in, or elimination of, hepatic tumour growth, with a significant increase in survival, indicating that control of the primary tumour by immunotherapy was not a prerequisite for containment of systemic disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 262, Issue 1, 8 April 2008, Pages 94–102
Journal: Cancer Letters - Volume 262, Issue 1, 8 April 2008, Pages 94–102
نویسندگان
J.P. Cashman, J.O. Larkin, G. Casey, M.C. Whelan, C. Collins, S. Aarons, M. Tangney, G.C. O’Sullivan,