کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2114964 | 1084565 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Crosstalk of hedgehog and Wnt pathways in gastric cancer
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Crosstalk of hedgehog and Wnt pathways in gastric cancer Crosstalk of hedgehog and Wnt pathways in gastric cancer](/preview/png/2114964.png)
چکیده انگلیسی
Morphogenic signals like Hedgehog (Hh) and Wnt are reported to play critical roles in the progression of gastric cancer. We aimed to assess the relationship between Hh and Wnt signaling pathways. In 58 gastric cancer specimens, Wnt pathway activation was inversely correlated with Hh pathway activation. When AGS gastric cancer cells, in which Wnt signaling was constitutively active, were used as a target cell line, Gli1 overexpression suppressed Wnt transcriptional activity, nuclear β-catenin accumulation and proliferation of AGS cells. Knock-down of β-catenin by siRNA suppressed Wnt pathway activity and proliferation of AGS cells. Our data may provide some clues for the treatment of gastric cancer associated with Wnt signaling activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 263, Issue 1, 8 May 2008, Pages 145–156
Journal: Cancer Letters - Volume 263, Issue 1, 8 May 2008, Pages 145–156
نویسندگان
Kosuke Yanai, Masafumi Nakamura, Takashi Akiyoshi, Shuntaro Nagai, Junji Wada, Kenichiro Koga, Hirokazu Noshiro, Eishi Nagai, Masazumi Tsuneyoshi, Masao Tanaka, Mitsuo Katano,