کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115306 | 1084587 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anticancer activity of a ceramide analog containing a disulfide linkage
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anticancer activity of a ceramide analog containing a disulfide linkage Anticancer activity of a ceramide analog containing a disulfide linkage](/preview/png/2115306.png)
چکیده انگلیسی
The effects of exogenous short-chain ceramide (1) on the arrest of growth of cancer cells in vitro and induction of apoptosis have been well documented. In the present study, an analog of 1 with a disulfide linkage, N-(4â²,5â²-dithiaheptanoyl)-d-erythro-ceramide (2), was synthesized and found to be significantly more antiproliferative and cytotoxic than 1 in BT549, A549, and DU145 cancer cells. The activity was correlated with a reduction in cellular glutathione (GSH) level. Ceramide analogs with a tri- and tetra-sulfide moiety were also prepared, but they did not deplete cellular GSH levels and did not possess antiproliferative or cytotoxic properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 251, Issue 1, 18 June 2007, Pages 53-58
Journal: Cancer Letters - Volume 251, Issue 1, 18 June 2007, Pages 53-58
نویسندگان
Robert Bittman, Zaiguo Li, Pranati Samadder, Gilbert Arthur,