کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115452 | 1546703 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Difference of growth-inhibitory effect of Scutellaria baicalensis-producing flavonoid wogonin among human cancer cells and normal diploid cell
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Methanol extract from cultured Scutellaria baicalensis cells inhibited the proliferation of human monocytic leukemia cell line THP-1 and human osteogenic sarcoma cell line HOS. The inhibitory effects of baicalin, baicalein and wogonin, the three major flavonoids contained in the extract, were studied. It should be noted that wogonin did not show the inhibitory effect on human fetal lung normal diploid cell line TIG-1, as compared to the inhibition observed in cancer cells. Physiological analyses in THP-1 cells showed that wogonin induced cell cycle arrest at G2/M phase and apoptosis. This is the first report discovering a cancer-specific apoptosis-inducing activity of wogonin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 245, Issues 1–2, 8 January 2007, Pages 269–274
Journal: Cancer Letters - Volume 245, Issues 1–2, 8 January 2007, Pages 269–274
نویسندگان
Mika Himeji, Takashi Ohtsuki, Harumi Fukazawa, Miho Tanaka, Shin-ichi Yazaki, Sadaharu Ui, Koji Nishio, Hisako Yamamoto, Kachio Tasaka, Akio Mimura,