کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115549 | 1546702 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells](/preview/png/2115549.png)
چکیده انگلیسی
A human neuroblastoma cell line, IMR-32, was used as an in vitro model system to study the effects of arsenic trioxide (As2O3) on aggressive human neuroblastoma. From 0.5 μM, As2O3 exhibited a dose-dependent inhibition of IMR-32 proliferation. At concentrations of 1.5 μM or higher, As2O3 up-regulated caspase 3, leading to cellular apoptosis. However, neurofilament-200 kDa and tyrosine hydroxylase were not up-regulated, implying minimal neuronal differentiation. Concomitantly, TrkA was down-regulated and TrkB up-regulated. Pre-treatment with the protein kinase C (PKC) inhibitor Ro-31-8220 partially blocked As2O3-mediated apoptosis, meaning that As2O3 might signal through PKC activation. The results suggest that As2O3 might be potentially useful in neuroblastoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 246, Issues 1â2, 8 February 2007, Pages 122-128
Journal: Cancer Letters - Volume 246, Issues 1â2, 8 February 2007, Pages 122-128
نویسندگان
William M.W. Cheung, Patrick W.K. Chu, Yok L. Kwong,