کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115562 | 1546702 | 2007 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Cyr61 is a multifunctional protein that can stimulate angiogenesis and tumor growth. Its expression by many cancers and breast cancers increases with tumor grade. Cyr61 is closely related to connective tissue growth factor, CTGF. Both proteins regulate skeletal development, suggesting that they could contribute to breast cancer metastases to bone, a process regulated by TGFβ. We show that Cyr61 transcription is activated by TGFβ and that the human Cyr61 promoter contains consensus sequences that bind Smad proteins. TGFβ in the tumor microenvironment may stimulate cancer metastases to sites such as bone by increasing Cyr61 expression and secretion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 246, Issues 1–2, 8 February 2007, Pages 230–236
Journal: Cancer Letters - Volume 246, Issues 1–2, 8 February 2007, Pages 230–236
نویسندگان
Laurent Bartholin, Lisa L. Wessner, John M. Chirgwin, Theresa A. Guise,