کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115674 | 1084604 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Correlation between reduction potentials and inhibitory effects on Epstein–Barr virus activation by emodin derivatives
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Correlation between reduction potentials and inhibitory effects on Epstein–Barr virus activation by emodin derivatives Correlation between reduction potentials and inhibitory effects on Epstein–Barr virus activation by emodin derivatives](/preview/png/2115674.png)
چکیده انگلیسی
As a continuation of studies using natural and synthetic products as cancer chemopreventive agents, we examined the reduction–oxidation potentials of hydroxylated emodin derivatives prepared from emodin in phosphate buffer at pH 7.2 using cyclic voltammetry. A significant correlation was found between the reduction potentials and number of the hydroxyl groups and the inhibitory effects of the hydroxylated emodin derivatives on Epstein–Barr virus early antigen activation. The electronic properties, i.e. LUMO energy and atomic charges of carbon at the 9-position (C9) and oxygen at the 11-position (O11), may also be useful for estimating the inhibitory effect on EBV-EA activation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 241, Issue 2, 28 September 2006, Pages 263–267
Journal: Cancer Letters - Volume 241, Issue 2, 28 September 2006, Pages 263–267
نویسندگان
Junko Koyama, Munetaka Inoue, Izumi Morita, Norihiro Kobayashi, Toshiyuki Osakai, Hoyoku Nishino, Harukuni Tokuda,