کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2115759 1084609 2006 8 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers
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موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Increased protein expression of both inducible nitric oxide synthase and cyclooxygenase-2 in human colon cancers
چکیده انگلیسی
The present study was conducted to investigate protein levels of inducible NO synthase (iNOS) and cayclooxygenase-2 (COX-2) in human colon cancer tissues. Significant increase of iNOS and COX-2 levels in tumors as compared to paired normal tissue was observed in 15 and 28, respectively, of 29 cases investigated. No correlation was observed between the two enzymes, and immunohistochemically demonstrated iNOS expression was mainly observed in tumor epithelial cells and was higher in well-differentiated than moderately-differentiated adenocarcinomas, while COX-2 expression was mainly detected in stromal cells and higher in Dukes' C and D than Dukes' A and B cases. These results suggest that iNOS and COX-2 have separate roles in colon carcinogenesis, and might both be usefully targeted by chemoprevention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 239, Issue 2, 8 August 2006, Pages 246-253
نویسندگان
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