کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2115786 | 1084610 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
PPAR-γ ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: PPAR-γ ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells PPAR-γ ligands and amino acid deprivation promote apoptosis of melanoma, prostate, and breast cancer cells](/preview/png/2115786.png)
چکیده انگلیسی
The PPAR-γ ligands, 15-deoxy-Δ12,14-prostaglandin J2 and ciglitazone, and the PPAR-α ligand, WY-14643, were examined for their effects on proliferation and apoptosis of A375 melanoma, DU145 and PC3 prostate cancer, and MB-MDA-231 breast cancer. While 15-deoxy-Δ12,14-prostaglandin J2 inhibited proliferation of A375 melanoma, ciglitazone was inactive against this and the other cell lines. Restriction of specific amino acids known to inhibit proliferation and induce apoptosis sensitized all cell lines to ciglitazone, and the combined effects were greater than the individual effects of either treatment. WY-14643 alone or in combination with amino acid deprivation was inactive. Normal fibroblasts were resistant to the treatments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 236, Issue 1, 8 May 2006, Pages 133–141
Journal: Cancer Letters - Volume 236, Issue 1, 8 May 2006, Pages 133–141
نویسندگان
Nomelí P. Núñez, Huaitian Liu, Gary G. Meadows,