کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2115896 1084615 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
NCOR1 mRNA is an independent prognostic factor for breast cancer
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
NCOR1 mRNA is an independent prognostic factor for breast cancer
چکیده انگلیسی

The transcriptional function of estrogen receptor alpha (ERα) can be modulated by co-regulatory proteins. In the present study, therefore, the level of expression of one of the co-regulator Nuclear Receptor Co-repressor 1 (NCOR1) mRNA has been assessed by quantitative real-time RT-PCR in 160 cases of invasive breast carcinoma. It was found that NCOR1 mRNA was expressed at significantly higher levels in patients over 50 years of age, without axillary lymph node involvement, with tumor size less than 2 cm, with low or intermediate histological grade, with ERα/PgR-positive and with HER2 negative tumors. Patients with high levels of expression of NCOR1 mRNA have a better prognosis than those with low expression. Univariate and multivariate prognostic analysis demonstrated that NCOR1 mRNA is an independent prognostic factor for breast cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 237, Issue 1, 8 June 2006, Pages 123–129
نویسندگان
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