کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2116021 1084621 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Paclitaxel suppresses the growth of primary prostate tumours (RM-1) and metastases in the lung in C57BL/6 mice
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Paclitaxel suppresses the growth of primary prostate tumours (RM-1) and metastases in the lung in C57BL/6 mice
چکیده انگلیسی

Paclitaxel has potent anti-cancer effects through its ability to block metaphase/anaphase transition during cell mitosis. This study shows that paclitaxel can significantly suppress both primary orthotopic murine (RM-1) prostate tumour growth (up to 60%) and the formation of pseudometastatic tumour colony formation in the lungs (by up to 46%) in C57BL/6 mice in vivo. Tumour growth suppression was associated with increased RM-1 cell apoptosis in the primary prostate tumours. In vitro studies found that the duration of exposure time to Paclitaxel was correlated with its ability to suppress cell proliferation and induce G2/M arrest.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 233, Issue 1, 20 February 2006, Pages 185–191
نویسندگان
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