کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2116051 1084623 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ptc1 heterozygous knockout mice as a model of multi-organ tumorigenesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Ptc1 heterozygous knockout mice as a model of multi-organ tumorigenesis
چکیده انگلیسی

Mutations in the Ptc1 gene are responsible for basal cell nevus (BCN) syndrome, and are commonly found in sporadic basal cell carcinomas (BCC) and in medulloblastoma (MB). Ptc1 hemizygosity in mice underlies this model's susceptibility to multi-organ tumorigenesis. Similar to BCN syndrome patients, the Ptc1 mouse model is characterized by tumor predisposition and radiation hypersensitivity. Ptc1+/− mice develop spontaneous rhabdomyosarcoma (RMS) and medulloblastoma (MB), as well as BCC following radiation exposure. The close phenotypic resemblance to the human disease makes these mice a unique preclinical model to test chemopreventive and therapeutic interventions.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 234, Issue 2, 28 March 2006, Pages 124–134
نویسندگان
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