کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116329 | 1084835 | 2013 | 9 صفحه PDF | دانلود رایگان |

TMEM166 is a novel programmed cell death-related molecule. In this report, we constructed a recombinant adenovirus 5-TMEM166 vector (Ad5-TMEM166) and evaluated its expression and anti-tumor activities in vitro and in vivo. Cell viability analysis revealed that the adenovirus-mediated increase of TMEM166 inhibited tumor cell growth in a dose- and time-dependent manner. This inhibitory effect was mediated by both autophagy (via inhibition of mTOR and activation of p70S6K) and apoptosis (via caspase-3 activation), both of which contributed to cell death and suppression of tumorigenicity. Our data indicated that Ad5-TMEM166 may be a novel gene therapy candidate for cancer.
► Ad5-TMEM166 inhibits tumor cell growth in vitro and in vivo.
► Ad5-TMEM166 induces cancer cell autophagy via mTOR/p70S6K pathway.
► Ad5-TMEM166 induces cancer cell apoptosis via caspase-3 activation.
► Ad5-TMEM166 may be a novel gene therapy candidate for cancer.
Journal: Cancer Letters - Volume 328, Issue 1, 1 January 2013, Pages 126–134