کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2116658 | 1085015 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Interaction between interleukin-1β â31T/C gene polymorphism and drinking and smoking habits on the risk of hepatocellular carcinoma among Japanese
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The risk of hepatocellular carcinoma (HCC) increases with the severity of hepatic inflammation. Interleukin (IL)-1β and tumor necrosis factor (TNF)-α are proinflammatory cytokines with multiple biological effects and may play essential roles in inflammation-linked tumor development. We conducted a case-control study including 209 incident HCC cases and two control groups (275 hospital controls and 381 patients with chronic liver disease [CLD] without HCC) to investigate whether IL-1B and TNF-A gene polymorphisms influence HCC susceptibility with any interaction with alcohol and tobacco. By comparing HCC cases with CLD patients, we found that IL-1B â31T/C polymorphism was associated with HCC risk among never drinkers and current smokers; adjusted odds ratios (and 95% confidence intervals) for C/T and T/T genotypes compared with C/C genotype were 1.70 (0.76-3.77) and 2.46 (1.05-5.76) (P trend = 0.03), respectively, among never drinkers, and 1.53 (0.60-3.99) and 2.54 (0.81-7.95) (P trend = 0.11), respectively, among current smokers. Similarly, HCC risk associated with heavy alcohol intake and current smoking differed by this polymorphism among CLD patients. IL-1B â31T/C polymorphism may modify HCC risk in relation to alcohol intake or smoking.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 271, Issue 1, 18 November 2008, Pages 98-104
Journal: Cancer Letters - Volume 271, Issue 1, 18 November 2008, Pages 98-104
نویسندگان
Tatsuhiko Sakamoto, Yasuki Higaki, Megumi Hara, Masayoshi Ichiba, Mikako Horita, Toshihiko Mizuta, Yuichiro Eguchi, Tsutomu Yasutake, Iwata Ozaki, Kyosuke Yamamoto, Shingo Onohara, Seiji Kawazoe, Hirohisa Shigematsu, Shunzo Koizumi, Keitaro Tanaka,