کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2116849 1085039 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel peptide that selectively binds highly metastatic hepatocellular carcinoma cell surface is related to invasion and metastasis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
A novel peptide that selectively binds highly metastatic hepatocellular carcinoma cell surface is related to invasion and metastasis
چکیده انگلیسی

Using a phage display approach, we identified AWYPLPP peptide as a specific peptide ligand that binds to the cell surface of highly metastatic human hepatocellular carcinoma (HCC). Moreover, the peptide was able to promote in vitro invasion of highly metastatic HCC cells by activating matrix metalloproteinase-9 and in vivo lung metastasis of HCC tumors. These results indicate that AWYPLPP peptide likely recognizes a novel receptor that is selectively expressed on the cell surface of highly metastatic HCC and mediates cellular activities associated with the invasive phenotype. Identification of the receptor for the AWYPLPP peptide may provide new insights into the molecular mechanism of HCC metastasis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 247, Issue 2, 18 March 2007, Pages 234–242
نویسندگان
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