کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2117044 1085192 2016 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radiothérapie guidée par l'image pour les petits animaux : une nouvelle ère pour les études précliniques
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Radiothérapie guidée par l'image pour les petits animaux : une nouvelle ère pour les études précliniques
چکیده انگلیسی
Preclinical external beam radiotherapy irradiations used to be delivered with a static broad beam. To promote the transfer from animal to man, the preclinical treatment techniques dedicated to the animal have been optimized to be similar to those delivered to patients in clinical practice. In this context, preclinical irradiators have been developed. Due to the small sizes of the animals, and the irradiation beams, the scaling to the small animal dimensions involves specific problems. Reducing the size and energy of the irradiation beams require very high technical performance, especially for the mechanical stability of the irradiator and the spatial resolution of the imaging system. In addition, the determination of the reference absorbed dose rate must be conducted with a specific methodology and suitable detectors. To date, three systems are used for preclinical studies in France. The aim of this article is to present these new irradiators dedicated to small animals from a physicist point of view, including the commissioning and the quality control.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer/Radiothérapie - Volume 20, Issue 1, February 2016, Pages 43-53
نویسندگان
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