کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2120408 | 1085690 | 2009 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies Role of the hypoxic tumor microenvironment in the resistance to anti-angiogenic therapies](/preview/png/2120408.png)
Angiogenesis, a key process for the growth of human cancers, has recently been exploited for the development of a novel class of cancer therapeutics that was thought to have wide applications and not to induce resistance in the clinical setting. Indeed, anti-angiogenic therapy has become an important option for the management of several human malignancies. However, a significant number of patients either do not respond to anti-angiogenic agents or fairly rapidly develop resistance. In addition, the benefit of anti-angiogenic therapy is relatively short-lived and the majority of patients eventually relapses and progresses. Several mechanisms of resistance to anti-angiogenic therapy have been recently proposed. The current review focuses on the role of intra-tumor hypoxia as a mechanism of resistance to anti-angiogenic agents and speculates on therapeutic approaches that might circumvent resistance and thereby improve clinical outcome.
Journal: Drug Resistance Updates - Volume 12, Issue 3, June 2009, Pages 74–80