کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2124508 | 1547257 | 2007 | 10 صفحه PDF | دانلود رایگان |
To investigate the associations between intake of antioxidant nutrients and risk of basal cell (BCC) and squamous cell carcinomas (SCC) of the skin, we carried out a prospective study among 1001 randomly selected adults living in an Australian community. Intake of antioxidants was estimated in 1996. Incident, histologically-confirmed BCC and SCC were recorded between 1996 and 2004. High dietary intake of lutein and zeaxanthin was associated with a reduced incidence of SCC in persons who had a history of skin cancer at baseline (highest versus lowest tertile, multivariable adjusted relative risk (RR) = 0.47, 95% confidence interval (CI): 0.25–0.89; P for trend = 0.02). In persons without a history of skin cancer at baseline, development of BCC was positively associated with intake of vitamins C and E from foods plus supplements (RR = 3.1, 95% CI: 1.1–8.6; P for trend = 0.03 and RR = 2.6, 95% CI: 1.1–6.3; P for trend = 0.02, respectively). In those with a skin cancer history at baseline, dietary intake in the second tertile for β-carotene (multivariable adjusted RR = 2.2, 95% CI: 1.2–4.1) and for vitamin E (multivariable adjusted RR = 2.1, 95% CI: 1.1–3.9) was associated with increased BCC risk, with no trend, and similar results were seen in those with a specific history of BCC. These data suggest quite different associations between antioxidant intake and SCC compared with BCC, consistent with other evidence of their different causal pathways.
Journal: European Journal of Cancer - Volume 43, Issue 18, December 2007, Pages 2707–2716