کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2125890 | 1547276 | 2006 | 8 صفحه PDF | دانلود رایگان |

The accurate determination of HER-2 in invasive breast cancer has become a critical issue, particularly in the context of the results of recent trastuzumab (Herceptin®) adjuvant trials. This multicentre study evaluated inter-observer reproducibility in interpretation of HER-2 immunostains performed in different laboratories according to their in-house technique. A total of 74 HER-2 immunostains were evaluated by 16 pathologists and by a central review committee. As determined by central review, the HER-2 score was 0 in 33 cases (44%), 1+ in 10 cases (13%), 2+ in 9 cases (12%) and 3+ in 23 cases (31%). The overall kappa value was good (kappa = 0.75). Agreement was excellent for the 0/1+ group (kappa = 0.85) and for the 3+ group (kappa = 0.82). As expected, the score 2+ group showed poor agreement (kappa = 0.38). A quality assurance process showed that ring studies and adherence to national guidelines greatly improve inter-observer reproducibility.
Journal: European Journal of Cancer - Volume 42, Issue 17, November 2006, Pages 2946–2953