کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2126234 1547295 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transcription inhibition: A potential strategy for cancer therapeutics
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Transcription inhibition: A potential strategy for cancer therapeutics
چکیده انگلیسی

Interference with transcription triggers a stress response leading to the induction of the tumour suppressor p53. If transcription is not restored within a certain time frame cells may undergo apoptosis in a p53-dependent and independent manner. The mechanisms by which blockage of transcription induces apoptosis may involve diminished levels of anti-apoptotic factors, inappropriate accumulation of proteins in the nucleus, accumulation of p53 at mitochondria or complications during replication. Many chemotherapeutic agents currently used in the clinic interfere with transcription and this interference may contribute to their anti-cancer activities. Future efforts should be directed towards exploring whether interference of transcription could be used as an anti-cancer therapeutic strategy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 41, Issue 16, November 2005, Pages 2569–2576
نویسندگان
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