کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2126249 | 1547273 | 2007 | 9 صفحه PDF | دانلود رایگان |
BackgroundChemotherapy-induced nausea and vomiting (CINV) remains a major adverse effect of cancer therapy. We aimed to determine outcomes associated with use of aprepitant in outpatients undergoing highly emetogenic chemotherapy in Germany from a patient’s and payer’s perspective.MethodsA decision–analytic model compared an aprepitant regimen (aprepitant/ondansetron/dexamethasone) to a control regimen (ondansetron/dexamethasone) over a five days period. Clinical results and resource utilisation observed in aprepitant phase III clinical trials were assigned German unit cost data.ResultsComplete response over one chemotherapy cycle was observed in 68% of patients in the aprepitant group (N = 514) compared to 48% of patients in the control group (N = 518). Patients were estimated to have gained an equivalent of 15 additional hours of perfect health per cycle (0.63 quality-adjusted life days) with aprepitant-based regimen compared to control regimen. Cost per quality-adjusted life year gained with aprepitant was estimated at €28,891.ConclusionsAprepitant substantially improved CINV-related health outcomes in patients undergoing highly emetogenic chemotherapy. Incremental benefits materialised in a cost-effective fashion.
Journal: European Journal of Cancer - Volume 43, Issue 2, January 2007, Pages 299–307