کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2126473 | 1547293 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Space-time clustering patterns of gliomas in the Netherlands suggest an infectious aetiology
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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![عکس صفحه اول مقاله: Space-time clustering patterns of gliomas in the Netherlands suggest an infectious aetiology Space-time clustering patterns of gliomas in the Netherlands suggest an infectious aetiology](/preview/png/2126473.png)
چکیده انگلیسی
To test the hypothesis that infectious exposures may be involved in glioma aetiology, we have analysed space-time clustering and seasonal variation using population-based data from the South of the Netherlands between 1983 and 2001. Knox tests for space-time interactions between cases were applied, with spatial coordinates of the addresses at time of diagnosis, and with distance to the Nth nearest neighbour. Data were also analysed by a second order procedure based on K-functions. Tests for heterogeneity and Edwards' test for sinusoidal variation were applied to examine seasonal variation of incidence. There was statistically significant space-time clustering in the Eastern, but not in the Western part of the region. Clustering was only present in adults, particularly in less densely populated areas. There was no evidence for seasonal variation. The results support a role for infectious exposures in glioma aetiology that may act preferentially in certain geographical areas.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Cancer - Volume 41, Issue 18, December 2005, Pages 2917-2923
Journal: European Journal of Cancer - Volume 41, Issue 18, December 2005, Pages 2917-2923
نویسندگان
M.P.W.A. Houben, J.W.W. Coebergh, J.M. Birch, C.C. Tijssen, C.M. van Duijn, R.J.Q. McNally,