The balance between risks and benefits: Long-term use of aromatase inhibitors

The adverse events associated with AI use are predictable and manageable. On the basis of current data, the tolerability of AIs in the adjuvant setting appears as good as that of tamoxifen, and some serious adverse events associated with tamoxifen use are avoided. Further studies and longer follow-up from current trials will help to determine in more detail the long-term effects of this class of drugs.