کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138008 1087865 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines
چکیده انگلیسی

The K562 cell line (chronic myeloid leukemia), sensitive to chemotherapy (non-MDR), and the Lucena cell line, resistant to chemotherapy (MDR) were investigated. The results suggest that both cell lines possess CD34+CD38− profiles of hematopoietic stem cell markers. The promoter regions of ABCB1, ABCG2 and ABCC1 genes contain binding sites for the Oct-4 transcripton factor, which is also considered a marker of tumor stem cells. Lucena cells showed an over-expression of the ABCB1 gene and a high expression of the Oct-4, ABCG2 and ABCC1 genes as compared to K562 cells.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 6, June 2010, Pages 757–762
نویسندگان
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