کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138389 1087875 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel gallium compound synergistically enhances bortezomib-induced apoptosis in mantle cell lymphoma cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
A novel gallium compound synergistically enhances bortezomib-induced apoptosis in mantle cell lymphoma cells
چکیده انگلیسی

Combination chemotherapy forms the backbone of cancer treatment. There is a need for new drug combinations for the treatment of mantle cell lymphoma (MCL). Herein, we show that gallium maltolate, a novel gallium compound, synergizes with bortezomib, a proteasome inhibitor, to induce cell death in MCL Granta cells. Cells exposed to either agent displayed caspase-3 activation, a loss of mitochondrial membrane potential, and a decrease in chymotrypsin-like activity. These effects were increased with both agents in combination. Our results show for the first time that the proteasome may be a target for gallium maltolate and suggest that the therapeutic potential of combination bortezomib and gallium maltolate warrants further investigation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 34, Issue 7, July 2010, Pages 950–953
نویسندگان
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