کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138417 1087876 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Strong correlation between VEGF and MCL-1 mRNA expression levels in B-cell chronic lymphocytic leukemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Strong correlation between VEGF and MCL-1 mRNA expression levels in B-cell chronic lymphocytic leukemia
چکیده انگلیسی

Expression of the anti-apoptotic myeloid cell leukemia-1 (MCL-1) gene is a novel prognostic factor in B-cell chronic lymphocytic leukemia (B-CLL). Vascular and endothelial growth factor (VEGF) and interleukin-6 (IL-6) are able to upregulate MCL-1 via autocrine signaling loops. In 88 B-CLL patients, we found a strong correlation of MCL-1 gene expression with VEGF (P < 10−7) but not with IL-6 mRNA levels. VEGF but not IL-6 expression influenced patient prognosis. VEGF may be a positive autocrine in vivo regulator of MCL-1 in B-CLL. Inhibition of VEGF and its signaling may prove to be useful in the treatment of B-CLL patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 33, Issue 12, December 2009, Pages 1623–1626
نویسندگان
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