Keywords: ABC; ATP-binding cassette; AKT; V-Akt murine thymoma viral oncogene homolog; ALDH1; aldehyde dehydrogenase 1; AR; androgen receptor; Bad; Bcl-2-associated death promoter; Bak; Bcl-2 homologous antagonist killer; Bax; Bcl-2-associated X protein; Bcl-2; B-c
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Keywords: 4- Shogaol (PubChem CID: 9794897); 6- Shogaol (PubChem CID: 5281794); Apigenin (PubChem CID: 5280443); Berberine (PubChem CID: 2353); Bergamottin (PubChem CID: 5471349); Caffeic acid (PubChem CID: 689043)Capsaicin (PubChem CID: 1548943); Cardamonin (PubCh
Keywords: AAV; adeno-associated viruses; ADA; adenosine deaminase deficiency; APCs; antigen presenting cells; AuNC; gold nanoclusters; AuNPs; gold nanoparticles; AuNRs; gold nanorods; BBB; blood-brain barrier; Bcl-2; B-cell lymphoma 2; Cas; CRISPR-associated; ChNPs
Keywords: ABCB1; ATP-binding cassette sub-family B member 1; ABCG; ATP-binding cassette drug efflux transporters; ACD; autophagic cell death; AKT; alpha serine/threonine protein kinase; ALDH; aldehyde dehydrogenase; AMPK; AMP-activated protein kinase; AP; apurinic/
Keywords: ACC; acetyl-CoA carboxylase; ASTX; astaxanthin; BAMBI; BMP and activin membrane-bound inhibitor homolog; BDL; bile duct ligation; CCL4; chemokine (C-C motif) ligand 4; CCR; chemokine receptor C-C motif; ChREBP; carbohydrate response element binding protei
Keywords: Antitublin chemotherapeutics; Photoactivable nanoliposomes; Mcl-1; Energetic metabolism; Mitochondrial apoptosis;
Keywords: â¢OH; hydroxyl radical; 2,2-BP; 2,2-bipyridyl; ABC; ATP-binding cassette; AIF; apoptosis-inducing factor; AMPK; AMP-activated protein kinase; AMPKK; AMPK kinase; ANT; adenine nucleotide translocase; AP-1; activator protein 1; Apaf-1; protease activating
Keywords: Aptamer; Apoptosis; Targeted therapy; Intrinsic apoptosis pathway; Extrinsic apoptosis pathway; Intramer; Akt; PKB (protein kinase B); Bcl; B-cell lymphoma family protein; BH; Bcl-2 homology domain; Bmi-1; B lymphoma Mo-MLV insertion region 1; CD; cluster
Keywords: Heat shock protein 27; Sea perch; Nervous necrosis virus; Apoptosis; Interferon; HSP; heat shock protein; RGNNV; red spotted grouper nervous necrosis virus; IFN; interferon; Cyto; cytochrome c; APAF-1; apoptotic protease activating factor-1; Bcl-2; B-cell
Keywords: PD; Parkinson's disease; AD; Alzheimer's disease; ROS; reactive oxygen species; SNpc; substantia nigra pars compacta; MnSOD; manganese superoxide dismutase; CuSOD; copper superoxide dismutase; NO; nitric oxide; O2â; superoxide anion; ONOOâ; peroxy
Keywords: AAA; ATPases associated with diverse cellular activities; 17-AAG; 17-N-allylamino-17-demethoxygeldanamycin; ABC; ATP-binding cassette; ABCE1; ATP binding cassette subfamily E member 1; AD; Alzheimer's disease; AIF; apoptosis inducing factor; Akt; Alpha se
Keywords: Telomerase; TERT; Cancer stemness; CSCs; Positive feedback loops; Targeted anticancer therapy; ABC; ATP-binding cassette; Akt; protein kinase B; ALDH1; aldehyde dehydrogenase 1; BAX; BCL-2-associated protein X; BCL; B-cell lymphoma family protein; BMI-1;
Keywords: AM; adrenomedullin; AMF; autocrine motility factor; AML; acute myeloid leukemia; BCL; B-cell lymphoma; BCR; breakpoint cluster region; BM; bone marrow; CCL; chemokine (CâC motif) ligand; CML; chronic myeloid leukemia; ECM; extracellular matrix; EGF; epi
Keywords: APAP; acetaminophen; ALD; alcoholic liver disease; BAG4; Bcl2-associated athanogene 4; CCCP; carbonyl-cyanide m-chlorophenyl hydrazine; Clec16a; c-type lectin domain family 16, member A; Dfcp1; double FYVE-containing protein 1; DUB; deubiquitinating enzym
Keywords: PI3-K/Akt; ERK1/2; Mcl-1; NF-κB; IL-8ELISA, enzyme linked immuno sorbent assay; fMLP, formyl-methionine-leucine-phenylalanine; G-CSF, granulocyte colony stimulating factor; GM-CSF, granulocyte-macrophage colony stimulating factor; IκB, inhibitor of kappa
Keywords: Pin1; the peptidyl-prolyl cis-trans isomerase; SRC-3/AIB1; steroid receptor coactivator 3; FAK; focal adhesion kinase; Mcl-1; myeloid cell leukemia-1; p70S6K; ribosomal S6 kinase; Stat3; signal transducers and activators of transcription 3; PKB/Akt; serin
Keywords: OS; overall survival; MAPK; mitogen-activated protein kinase; RTKs; receptor tyrosine kinases; PI3K; phosphatidylinositide 3-kinases; GEFs; guanine nucleotide exchange factors; GAPs; GTPase-activating proteins; FTIs; farnesyltransferase inhibitors; mTOR;
Keywords: High-throughput screening; Protein-protein interaction inhibitor; Mcl-1; Bcl-xL; Hit compound validation;
Keywords: ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
Keywords: AA; arachidonic acid; ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPK; AMP-activated protein kinase; ANT; adenine nucleotide translocase; Apaf-1; apoptotic protease activating factor-1; ATP; adenosine triphosphate; ATP-ase; ATP synthase;
Keywords: AMPK; AMP activated protein kinase; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; ERK; extracellular signal-regulated kinase; FLIP; FLICE inhibitory protein; FAK; focal adhesion kinase; GSK-3;
Discovery of Mcl-1 inhibitors based on a thiazolidine-2,4-dione scaffold
Keywords: Mcl-1; Bcl-xL; Apoptosis; Cancer; Protein-protein interaction;
Upregulation of Mcl-1 inhibits JQ1-triggered anticancer activity in hepatocellular carcinoma cells
Keywords: BET inhibitor; Mcl-1; Hepatocellular carcinoma; Apoptosis;
ABT-199-mediated inhibition of Bcl-2 as a potential therapeutic strategy for nasopharyngeal carcinoma
Keywords: ABT-199; Apoptosis; Nasopharyngeal carcinoma; Bcl-2; Mcl-1;
Cyclocommunol induces apoptosis in human oral squamous cell carcinoma partially through a Mcl-1-dependent mechanism
Keywords: Cyclocommunol; Breadfruit; Oral cancer; Autophagy; Apoptosis; Mcl-1;
Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions
Keywords: 5-Fu; 5-fluorouracil; AL; avicularin; Bax; B-cell lymphoma 2 associated X; BCA; bicinchoninic acid; BOK; BCL-2-related ovarian killer; DDP; cisplatin; H&E; hematoxylin and eosin; Mcl-1; myeloid cell leukemia 1; MTT; 3-(4,5-dimethylthiazolyl-2)-2,5-dipheny
Discovery and development of substituted tyrosine derivatives as Bcl-2/Mcl-1 inhibitors
Keywords: Apoptosis; Bcl-2; Mcl-1; Tyrosine; Anti-tumor;
Modulation of Mcl-1 transcription by serum deprivation sensitizes cancer cells to cisplatin
Keywords: Apoptosis; Cancer; Chemotherapy; Mcl-1; Serum deprivation;
The role of XIAP in resistance to TNF-related apoptosis-inducing ligand (TRAIL) in Leukemia
Keywords: TRAIL; TNF-related apoptosis-inducing ligand; XIAP; X-linked inhibitor of apoptosis protein; cFLIP; cellular FLICE-inhibitory protein; bcl-2; B-cell lymphoma 2; IAP; inhibitor of apoptosis proteins; Mcl-1; myeloid cell leukemia-1; Apo-2L; Apo2 ligand; DR;
Garlic-derived compound S-allylmercaptocysteine inhibits hepatocarcinogenesis through targeting LRP6/Wnt pathway
Keywords: Axin1; axis inhibition protein 1; DKK-1; Dickkopf Wnt signaling pathway inhibitor 1; DVL2; disheveled 2; FADD; Fas-associated protein with death domain; HCC; hepatocellular carcinoma; KD; knock-down; LDH; lactate dehydrogenase; LRP6; low-density lipoprote
Glycogen synthase kinase 3β inhibition reduces mitochondrial oxidative stress in chronic myocardial ischemia
Keywords: metabolic syndrome; chronic coronary ischemia; glycogen synthase kinase 3B; oxidative stress; collagen; AIF; apoptosis inducing factor; CON; control group; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSK-3β; glycogen synthase kinase- 3β; GSK-3βI;
Dihydroartemisinin suppresses STAT3 signaling and Mcl-1 and Survivin expression to potentiate ABT-263-induced apoptosis in Non-small Cell Lung Cancer cells harboring EGFR or RAS mutation
Keywords: Dihydroartemisinin; ABT-263; STAT3; Mcl-1; Survivin; Bim;
The mechanism of tumour cell death by metal-based anticancer drugs is not only a matter of DNA interactions
Keywords: 15-LOX-1; 15-lipoxygenase; AIF; apoptosis inducing factor; APC; adenomatous polyposis coli; AKT or PKB; protein kinase B; ATG16L2; autophagy related 16 like 2; AUC; area under the curve; Bad; Bcl-2 associated death promoter; Bcl-2; B-cell lymphoma 2; Bcl-
miRNA meets plasma cells “How tiny RNAs control antibody responses”
Keywords: PC; plasma cell; PB; plasmablast; GC; germinal center; SHM; somatic hypermutation; CSR; class switch recombination; AID; activation-induced cytidine deaminase; Ig; immunoglobulin; Blimp-1; B-lymphocyte-induced maturation protein 1; DGCR8; DiGeorge syndrom
The pro-apoptotic protein Bmf co-operates with Bim and Puma in neuron death induced by β-amyloid or NGF deprivation
Keywords: Bmf; Bcl2 Modifying Factor; PUMA; p53 upregulated modulator of apoptosis; PC12; Pheochromocytoma cells; Bcl-2; B-cell lymphoma 2; BH3; Bcl-2 homology domain 3; Bim; Bcl-2 interacting mediator of cell death; Mcl-1; Myeloid cell leukemia 1; Bak; Bcl-2 antag
RASSF6-mediated inhibition of Mcl-1 through JNK activation improves the anti-tumor effects of sorafenib in renal cell carcinoma
Keywords: RASSF6; Sorafenib; Mcl-1; JNK signaling pathway; Apoptosis; Targeted therapy;
Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents
Keywords: Bcl-2; Mcl-1; Apoptosis; Anti-tumor; Inhibitors;
Hsa-microRNA-101-3p expression in human urinary bladder cancer: Correlation with tumor pathology
Keywords: BC; Bladder cancer; Bcl-2; B cell lymphoma-2; BTCC; Bladder transitional cell carcinoma; c-Met; Tyrosine-protein kinase Met; EZH2; Enhancer of zeste homologue 2; FGFR3; Fibroblast growth factor receptor 3; Hsa-microRNA-101-3p; Homosapiens micro RNA-101 st
Flexibility enables to discriminate between ligands: Lessons from structural ensembles of Bcl-xl and Mcl-1
Keywords: Bcl-xl; Mcl-1; Conformational flexibility; Principal component analysis; Ligand binding;
PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Keywords: CRPC; castration-resistant prostate cancer; ADT; androgen deprivation therapy; PI3K; phosphoinositide 3-kinase; AR; androgen receptor; PTEN; phosphatase and tensin homologue deleted on chromosome 10; INPP4B; inositol polyphosphate 4-phosphatase type II; P
Role of Mcl-1 in regulation of cell death in human induced pluripotent stem cell-derived cardiomyocytes in vitro
Keywords: Mcl-1; Bcl-xL; hiPSC-cardiomyocyte; Mitochondria; Apoptosis; Cardio-oncology;
Targeting autophagy by small molecule inhibitors of vacuolar protein sorting 34 (Vps34) improves the sensitivity of breast cancer cells to Sunitinib
Keywords: Autophagy; Combination therapy; Erlotinib; Vps34; High-content screening; AKT; Protein kinase B; ATG7; Autophagy-related protein 7; BafA1; Bafilomycin A1; Chk1; Checkpoint kinase 1; CQ; Chloroquine; FGFR; Fibroblast growth factor receptor; GFP; Green fluo
Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes
Keywords: Cytomegalovirus; Monocytes; Small-molecule inhibitor; HCMV; human cytomegalovirus; h; hour; EGF; epidermal growth factor; EGFR; EGF receptor; αvβ3; alpha v beta 3 integrin; gB; glycoprotein B; gH; glycoprotein H; PI3K; phosphoinositide 3-kinase; PTEN; p
Impact of microRNAs on ischemic stroke: From pre- to post-disease
Keywords: AAV; adeno-associated virus; ABCA1; ATP-binding cassette transporter 1; AGO; argonaute; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionate; AT1R; angiotensin II type 1 receptor; AQPs; aquaporins; BBB; blood-brain barrier; Bcl-6; B-cell lymphoma-6;
Expression of ERK and Akt proteins in women with unexplained first-trimester recurrent miscarriage
Keywords: Recurrent miscarriage; Pregnancy loss; ERK protein; Akt protein; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; MAPK; mitogen-activated protein kinase; MCL-1; myeloid leukemia cell-1; MMP; matrix metalloproteinase; PI3K; phospha
Protein kinase C-eta regulates Mcl-1 level via ERK1
Keywords: DAG; diacylglycerol; ERK; extracellular signal-regulated kinase; GSK3; glycogen synthase kinase-3; MAPK; mitogen-activated protein kinase; Mcl-1; myeloid cell leukemia-1; Mule; Mcl-1 ubiquitin ligase; PI3K; phosphatidylinositol 3-kinase; PKC; protein kina
KRIBB11 accelerates Mcl-1 degradation through an HSF1-independent, Mule-dependent pathway in A549 non-small cell lung cancer cells
Keywords: Mcl-1; KRIBB11; HSF1; Mule; USP9X; BIS;
MicroRNA hsa-miR-29b potentiates etoposide toxicity in HeLa cells via down-regulation of Mcl-1
Keywords: Mcl-1; Myeloid cell leukemia protein; Mcl-1L; Myeloid cell leukemia protein long; Mcl-1S; Myeloid cell leukemia protein short; Bak; Bcl-2 homologous antagonist/killer; BCL-2; B-cell lymphoma; FDA; Food and Drug Administration; 3â²UTR-region; 3â² untrans
Inhibition of Mcl-1 enhances Pevonedistat-triggered apoptosis in osteosarcoma cells
Keywords: Pevonedistat; Mcl-1; Apoptosis; Osteosarcoma;
Knockdown of microRNA-203 alleviates LPS-induced injury by targeting MCL-1 in C28/I2 chondrocytes
Keywords: LPS; lipopolysaccharide; TNF-α; tumor necrosis factor-α; miR-203; micro RNA 203; MCL-1; myeloid cell leukemia-1; JAK/STAT; Janus-activated kinase and signal transducer and activator of transcription; Osteoarthritis; MicroRNAâ203; MCL-1; LPS; Inflammat