دانلود مقالات ISI درباره Mcl-1 + ترجمه فارسی

Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival

Keywords: BH; Bcl-2 homology; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; DMEM; Dulbecco׳s modified Eagle׳s medium; PARP; poly (ADP-ribose) polymerase; Bcl-2; Bcl-xL; Mcl-1; Apoptosis; ABT-263;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The pleiotropic profile of the indirubin derivative 6BIO overcomes TRAIL resistance in cancer

Keywords: Apoptosis; TRAIL; Indirubin; Chemosensitizer; Mcl-1; Cancer;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Dicoumarol sensitizes renal cell carcinoma Caki cells to TRAIL-induced apoptosis through down-regulation of Bcl-2, Mcl-1 and c-FLIP in a NQO1-independent manner

Keywords: Dicoumarol; TRAIL; Bcl-2; Mcl-1; c-FLIP; NQO1;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Clitocine induces apoptosis and enhances the lethality of ABT-737 in human colon cancer cells by disrupting the interaction of Mcl-1 and Bak

Keywords: Clitocine; ABT-737; Apoptosis; Mcl-1; Bak;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

PI3K/mTOR dual inhibitor NVP-BEZ235 decreases Mcl-1 expression and sensitizes ovarian carcinoma cells to Bcl-xL-targeting strategies, provided that Bim expression is induced

Keywords: Ovarian cancer; Mcl-1; Bim; NVP-BEZ235; ABT-737; ERK1/2;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation

Keywords: Bcl-2; B-cell lymphoma 2; Casp-3; caspase-3; CHX; cycloheximide; CG; cardiac glycoside; DMSO; dimethyl sulfoxide; D6-MA; α-l-rhamnose monosaccharide derivative; ECM; extracellular matrix; ERK; extracellular signal-regulated protein kinase; FAK; focal adh

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy

Keywords: JAK; Janus kinase; STAT; Signal Transducer and Activator of Transcription; ICER; inducible cAMP Early Repressor protein; c-myc; cellular regulatory gene that codes for a transcription factor; mcl-1; induced myeloid leukemia cell differentiation protein; b

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

A new goniothalamin N-acylated aza-derivative strongly downregulates mediators of signaling transduction associated with pancreatic cancer aggressiveness

Keywords: Goniothalamin; N-acylated aza-derivatives; Pancreatic cancer; Panc-1 cells; AXL kinase; HIF-1α; GSH; glutathione; AXL; tyrosine-protein kinase receptor; ERK1/2; extracellular signal-regulated kinases 1 and 2; HIF-1α; hypoxia-inducible factor-1α; ROS;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2014 سفارش ترجمه

Aspirin overcomes Navitoclax-resistance in hepatocellular carcinoma cells through suppression of Mcl-1

Keywords: Aspirin; Mcl-1; Navitoclax (ABT-263); Hepatocellular carcinoma;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells

Keywords: Breast cancer; Glucose deprivation; Mcl-1; S6K1; Survivin;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1

Keywords: MicroRNA; miR-133a; Apoptosis; Bcl-xL; Mcl-1; Osteosarcoma;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker

Keywords: Apoptosis; Mcl-1; Biomarkers; Oncology; Cell-based activity;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

The DEAD box proteins DDX5 (p68) and DDX17 (p72): Multi-tasking transcriptional regulators

Keywords: ERα; estrogen receptor alpha; CBP; CREB-binding protein; SRC-1; steroid receptor coactivator 1; SRA; steroid receptor RNA activator; RNA Pol II; RNA polymerase II; P/CAF; CBP/p300 associated factor; TFIIA; transcription factor IIA; AR; androgen receptor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Anisomycin treatment enhances TRAIL-mediated apoptosis in renal carcinoma cells through the down-regulation of Bcl-2, c-FLIP(L) and Mcl-1

Keywords: Anisomycin; TRAIL; Bcl-2; c-FLIP(L); Mcl-1;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Simultaneous knock-down of Bcl-xL and Mcl-1 induces apoptosis through Bax activation in pancreatic cancer cells

Keywords: Mcl-1; Bcl-xL; Bax; Pancreatic cancer; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Death of multiple myeloma cells induced by cAMP-signaling involves downregulation of Mcl-1 via the JAK/STAT pathway

Keywords: cAMP; Multiple myeloma; JAK; STAT; Mcl-1;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

The two directions of TNF-related apoptosis-inducing ligand in rheumatoid arthritis

Keywords: TRAIL; TNF-related apoptosis-inducing ligand; TNF; tumor necrosis factor; RA; rheumatoid arthritis; RANKL; Receptor Activator for Nuclear Factor κ B Ligand; FLSs; fibroblast like synoviocytes; FLIP; FLICE-like inhibitory protein; McL-1; induced myeloid l

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Effective response of doxorubicin-sensitive and -resistant breast cancer cells to combinational siRNA therapy

Keywords: siRNA; Mcl-1; Breast cancer; Animal model; Polycationic polymers; Drug resistance;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

NF-κB activation fails to protect cells to TNFα-induced apoptosis in the absence of Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w

Keywords: Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma-extra large; Bcl-w; Bcl-2-like protein 2; BH3; Bcl-2 homology 3; cIAP-2; cellular inhibitor of apoptosis protein 2; DMEM; Dulbecco' s modified eagle medium; ERK; extracellular signal-regulated kinase; FBS;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Modulation of Mcl-1 expression reduces age-related cochlear degeneration

Keywords: Mcl-1; Gene delivery; Cochlea; Aging; Intervention; Hair cells; Rat;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Therapeutic efficacy and molecular mechanisms of snake (Walterinnesia aegyptia) venom-loaded silica nanoparticles in the treatment of breast cancer- and prostate cancer-bearing experimental mouse models

Keywords: Bcl-2; B-cell lymphoma 2; Bcl-XL; B-cell lymphoma-extra large; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; Bim; Bcl-2-interacting mediator of cell death; CK; chemokine; CKRs; chemokine receptors; Mcl-1; myeloid cell leukemia

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Opposing Mcl-1, the GALIG proapoptotic gene is upregulated as neutrophils die and underexpressed in Acute Myeloid Leukemia cells

Keywords: GALIG; Apoptosis; MCL-1; Neutrophils; Acute Myeloid Leukemia; Bone marrow

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Resveratrol suppresses cell proliferation via inhibition of STAT3 phosphorylation and Mcl-1 and cIAP-2 expression in HTLV-1-infected T cells

Keywords: Resveratrol; STAT3; Mcl-1; cIAP-2; Adult T-cell leukemia

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Delving deeper: MCL-1's contributions to normal and cancer biology

Keywords: apoptosis; MCL-1; homeostasis; mitochondrial function; cancer; development

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Myeloid cell leukemia-1 is a key molecular target for mithramycin A-induced apoptosis in androgen-independent prostate cancer cells and a tumor xenograft animal model

Keywords: Prostate cancer; Apoptosis; Mithramycin A; Mcl-1; Xenograft

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking

Keywords: α-Helix; Quinazolone; Two-faced; Mcl-1; Bcl-2JQFLKAJQKGNCSW-UHFFFAOYSA-N; UGGKGLCTXKBKQS-UHFFFAOYSA-N; RNUPWQDKOJAKGW-UHFFFAOYSA-N; SYEGIOUDEHFYQT-UHFFFAOYSA-N

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach

Keywords: Mcl-1; Small molecule inhibitor; Fragment-based approach; AnticancerBcl-2, B-cell lymphoma 2; Mcl-1, myeloid cell leukemia sequence 1; Bcl-xL, B-cell lymphoma x long; Bax, Bcl-2-associated x protein; Bak, Bcl-2 homologous antagonist/killer; BH3, Bcl-2 hom

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors

Keywords: Fragment-based; Apoptosis; Mcl-1; LE; FQ

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Targeting apoptosis pathways by Celecoxib in cancer

Keywords: Celecoxib; Apoptosis; Mcl-1; Bcl-2; COX-2Akt, protein kinase B; ATF-4, activating transcription factor 4; CHOP/GADD153, c/EBP homologous transcription factor/growth arrest and DNA-damage associated protein 153; COXIB, COX-2-inhibitor; COX-2, Cyclooxygenas

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

CD44 activation enhances acute monoblastic leukemia cell survival via Mcl-1 upregulation

Keywords: CD44; AML; Survival; Mcl-1; THP-1; Acute monoblastic leukemia; Apoptosis resistance;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction

Keywords: Mcl-1; Bcl-2; Protein-protein interactions; Small molecule inhibitors; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Downregulation of Mcl-1 by daunorubicin pretreatment reverses resistance of breast cancer cells to TNF-related apoptosis-inducing ligand

Keywords: TRAIL; Daunorubicin; Mcl-1; Breast cancer; Apoptosis

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes

Keywords: Bcl-2; Mcl-1; Bim; Astrocyte; miR-181; Mitochondria;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibition of GSK-3β reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells

Keywords: A; AR-A014418, GSK-3β inhibitor; ANOVA; analysis of variance; ATF3; activating transcription factor 3; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-XL; B-cell lymphoma-extra large; DMSO; dimethyl sulfoxide; DOC-Na; sodium deoxycholate;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Mcl-1 regulates the survival of adult neural precursor cells

Keywords: Bcl-2; B cell lymphoma 2; Bcl-xL; B cell lymphoma X large fragment; CKO; conditional knockout; BrdU; Bromodeoxyuridine; Cre; Cre recombinase; CMV; cytomegalovirus; Dcx; Doublecortin; DIV; days in vitro; FGF-2; fibroblast growth factor 2; GFAP; glial fibri

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1α

Keywords: Apaf-1; apoptotic protease activating factor-1; Bcl-2; B cell lymphoma-2; Bcl-xL; B cell lymphoma-extra large; DCFH-DA; 2′,7′-dichlorofluorescein-diacetate; ECL; enzyme-linked chemiluminescence; FBS; fetal bovine serum; GAPDH; glyceraldehyde-3-phospha

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Mcl-1 determines the imiquimod-induced apoptosis but not imiquimod-induced autophagy in skin cancer cells

Keywords: Imiquimod; Mcl-1; Skin cancer cells; Basal cell carcinoma; Apoptosis; Autophagy

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

5-hydroxy-7-methoxyflavone inhibits N-formyl-l-methionyl-l-leucyl-l-phenylalanine-induced superoxide anion production by specific modulate membrane localization of Tec with a PI3K independent mechanism in human neutrophils

Keywords: MCL-1; Neutrophil; fMLP; Tec; Protein kinase C

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in vitro and in vivo

Keywords: Dihydroartemisinin; Apoptosis; Mcl-1; Bak; Hepatocellular carcinoma

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells

Keywords: Vinca alkaloids; Lung adenocarcinoma; Mitotic arrest; Apoptosis; ROS; JNK; Mcl-1; Mitochondria; Caspase

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Noxa controls Mule-dependent Mcl-1 ubiquitination through the regulation of the Mcl-1/USP9X interaction

Keywords: Noxa; Mcl-1; Ubiquitination; E3 ligase; USP9X

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Regulation of human hepatocellular carcinoma cells by Spred2 and correlative studies on its mechanism

Keywords: Spred2; Hepatocellular carcinoma; Migration; Mcl-1; SCID mouse;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Noxa induces apoptosis in oncogene-expressing cells through catch-and-release mechanism operating between Puma and Mcl-1

Keywords: Apoptosis; p53; Adenovirus E1A; Noxa; Puma; Mcl-1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Effective delivery of anti-miRNA DNA oligonucleotides by functionalized gold nanoparticles

Keywords: Anti-microRNA oligonucleotides (AMOs); Gold nanoparticles; miR-29; MCL-1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibition of xenograft tumor growth in mice by gold nanoparticle-assisted delivery of short hairpin RNAs against Mcl-1L

Keywords: Gold nanoparticle-assisted gene delivery system (AuNP-GDS); Short hairpin RNAs (shRNAs); Xenograft tumor; Mcl-1

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Overexpression of microRNA-29b induces apoptosis of multiple myeloma cells through down regulating Mcl-1

Keywords: Multiple myeloma; MicroRNA; Mcl-1; IL-6; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Mcl-1 downregulation by YM155 contributes to its synergistic anti-tumor activities with ABT-263

Keywords: IAP; inhibitors of apoptosis; NSCLC; non-small cell lung cancer; XIAP; X-linked inhibitor of apoptosis protein; DMSO; dimethyl sulfoxide; PARP; poly (ADP-ribose) polymerase; STAT3; signal transducer and activator of transcription 3; YM155; Mcl-1; Survivin

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

The gold compound auranofin induces apoptosis of human multiple myeloma cells through both down-regulation of STAT3 and inhibition of NF-κB activity

Keywords: Multiple myeloma; Auranofin; Apoptosis; Mcl-1; NF-κB; IL-6; JAK/STAT

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design

Keywords: Apoptosis; Mcl-1; Bcl-2; p2 pocket; Dual inhibitor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه