Inhibition of S6K1 enhances glucose deprivation-induced cell death via downregulation of anti-apoptotic proteins in MCF-7 breast cancer cells

► Inhibition of S6K1 sensitizes glucose deprivation induced cell death. ► The sensitization is through the downregulation of Mcl-1 and survivin. ► Inhibition of S6K1 may be a strategy for sensitizing cells to glucose deprivation.