دانلود مقالات ISI درباره Mcl-1 + ترجمه فارسی

Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok

Keywords: Bcl-2 proteins; Mitochondria; Calcium; Excitotoxicity; Bax; Bok; Δψm; mitochondrial membrane potential; Bcl-2; B cell lymphoma gene 2; BH; Bcl-2 homology region; Bax; Bcl-2-associated protein x; Bak; Bcl-2-antagonist/killer; Mcl-1; myeloid cell leukemia

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains

Keywords: Bcl-2; Mcl-1; Cancer; Pyrrolidine; Target;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleMACC1 regulates Fas mediated apoptosis through STAT1/3 - Mcl-1 signaling in solid cancers

Keywords: Solid cancers; MACC1; STAT signaling; Fas mediated apoptosis; Bcl-2 family proteins; MACC1; Metastasis associated in colon cancer 1; CRC; Colorectal cancer; STAT; Signal transducers and activators of transcription; JAK; Janus kinase; Mcl-1; Myeloid cell l

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors

Keywords: Apoptosis; Bcl-2; Mcl-1; Structure-based design;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Structure of a Myeloid cell leukemia-1 (Mcl-1) inhibitor bound to drug site 3 of Human Serum Albumin

Keywords: Mcl-1; Myeloid cell leukemia 1; HSA; Human Serum Albumin; BSA; Bovine Serum Albumin; FBS; Fetal Bovine Serum; FITC; fluorescein isothiocyanate; TR-FRET; time resolved fluorescence energy transfer; Human Serum Albumin; Free fraction; Apoptosis; Cancer; Mcl

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin in hypopharyngeal carcinoma cells

Keywords: CDK9 inhibition; Hypopharyngeal squamous cell carcinoma; Apoptosis; Chemosensitization; Mcl-1; Cisplatin;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

BH3-only protein BIM: An emerging target in chemotherapy

Keywords: A1; Bcl-2-related protein A1; Apaf-1; Apoptotic protease-activating factor 1; ASK1; Apoptosis Signal Regulated Kinase 1; Bad; Bcl-2 associated agonist of cell death; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2-associated X protein; Bcl-2; B-cell l

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Trichodermin induces c-Jun N-terminal kinase-dependent apoptosis caused by mitotic arrest and DNA damage in human p53-mutated pancreatic cancer cells and xenografts

Keywords: Pancreatic cancer; Mitotic arrest; DNA damage; Apoptosis; c-Jun N-terminal kinase; Trichodermin; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra long; CDK; cyclin-dependent kinase; Cdc; cell division cycle; DSBs; double-strand breaks; DUSP1; dual

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2017 سفارش ترجمه

Multifaceted anticancer activity of BH3 mimetics: Current evidence and future prospects

Keywords: A1; Bcl-2-related protein A1; AIF; apoptosis-inducing factor; AKT; protein kinase B; AMPK; 5′AMP-activated protein kinase; Bad; Bcl-2-associated death promoter; Bak; Bcl-2-associated killer; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

NAP1L1 regulates NF-κB signaling pathway acting on anti-apoptotic Mcl-1 gene expression

Keywords: NF-κB; nuclear factor-κB; Bcl-2; B cell lymphoma protein 2; Bcl-xl; Bcl-2-related protein long form of Bcl-x; Mcl-1; myeloid cell leukemia 1; Bax; bcl-2-associated X protein; NAPs; nucleosome assembly proteins; NAP1L; NAP1 like protein; ΔΓΚζ; diacyl

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Perifosine and ABT-737 synergistically inhibit lung cancer cells in vitro and in vivo

Keywords: Lung cancer; ABT-737; Perifosine; Mcl-1; Synergism;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Research reportThe role of myocardin-related transcription factor-A in Aβ25-35 induced neuron apoptosis and synapse injury

Keywords: MRTF-A; Myocardin-related transcription factor-A; SRF; serum response factor; Mcl-1; Myeloid cell leukemia-1; Arc; activity-regulated cytoskeletal-associated protein; IEGs; immediate early genes; F-actin; filamentous actin; Alzheimer; MRTF-A; Mcl-1; Arc;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Jaceosidin induces apoptosis through Bax activation and down-regulation of Mcl-1 and c-FLIP expression in human renal carcinoma Caki cells

Keywords: Jaceosidin; Apoptosis; Bax; c-FLIP; Mcl-1; Renal cancer;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Original ArticleRepression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couple ER stress to mitochondrial apoptosis

Keywords: Apoptosis; Myeloma; Mcl-1; Bak; ER stress; MM; multiple myeloma; HMCLs; Human myeloma cell line(s); Tg; Thapsigargin; CHX; cycloheximide;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Role of microRNA-29b in myelodysplastic syndromes during transformation to overt leukaemia

Keywords: Myelodysplastic syndromes; blasts; bone marrow; miR-29; MCL-1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells

Keywords: LGALS3; Galectin 3; LGALS1; Galectin 1; AML; Acute myeloid leukemia; qRT-PCR; Real-time PCR; AKT; Protein kinase B; ERK; Extracellular receptor kinase; BCL2; B cell lymphoma 2; BCL-XL; B cell lymphoma 2 Like 1; MCL-1; Myeloid cell leukemia 1; Ph +;  Phi

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Negative control of TRAIL-R1 signaling by transforming growth factor β1 in pancreatic tumor cells involves Smad-dependent down regulation of TRAIL-R1

Keywords: ALK5; activin receptor-like kinase 5; Bcl-xL; B-cell lymphoma-extra large; DISC; death inducing signaling complex; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; FADD; Fas-associated protein with death domain; FLIP; FLICE-like i

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis

Keywords: MCL-1; MYC; p53; BIM; apoptosis; lymphoma

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer

Keywords: Warburg effect; Autophagy; PTEN; TP53; Hexokinase 2; AMPK; ULK-1; MCL-1; 2-Deoxy-glucose; Chloroquine; Androgen receptor; Castration-resistant prostate cancer; Genetically-engineered mouse model

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Structure-based design of N-substituted 1-hydroxy-4-sulfamoyl-2-naphthoates as selective inhibitors of the Mcl-1 oncoprotein

Keywords: Mcl-1; Bcl-xL; Protein-protein interaction; Apoptosis; Cancer;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Oxidized LDL induced extracellular trap formation in human neutrophils via TLR-PKC-IRAK-MAPK and NADPH-oxidase activation

Keywords: 4-HNE; 4-hydroxynonenal; ABAH; 4-aminobenzoic acid hydrazide; ApoB; Aproprotein B 100; BSA; bovine serum albumin; CD; cluster of differentiation; DAPI; 4ʹ,6-diamidino-2-phenylindole; DCF-DA; 2,7-dichlorofluorescein diacetate; DFP; diisopropyl fluorophosp

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice

Keywords: COX-2; cyclooxygenase-2; PGE2; prostaglandin E2;; RCD; regular chow diet; MCD; methionine and choline deficient diet; CCl4; carbon tetrachloride; NAFLD; non-alcoholic fatty liver disease; NL; normal liver; NAS; non-alcoholic steatosis; NASH; non-alcoholic

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

Matrine suppresses proliferation and induces apoptosis in human cholangiocarcinoma cells through suppression of JAK2/STAT3 signaling

Keywords: Ac-DEVD-CHO; N-acetyl-Asp-Glu-Val-Asp-aldehyde; EGCG; epigallocatechin-3-gallate; IL-6; interleukin-6; JAK; Janus kinase; JC-1; 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimi-dazolylcarbocyanine iodide; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-dip

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

YM155 suppresses cell proliferation and induces cell death in human adult T-cell leukemia/lymphoma cells

Keywords: YM155; Surviving; STAT3; Mcl-1; Adult T-cell leukemia

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Tyrosine kinase inhibitor tyrphostin AG490 triggers both apoptosis and autophagy by reducing HSF1 and Mcl-1 in PEL cells

Keywords: STAT3; Signal Transducer and Activator of Transcription 3 (gene); HSF1; Heat Shock Transcription Factor 1; HSP70; Heat Shock Protein 70; Mcl-1; Myeloid Cell Leukemia 1; LC3; Microtubule-Associated protein 1 light chain 3; p62; Sequestosome1/SQSTM1; PEL; P

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

AML sensitivity to YM155 is modulated through AKT and Mcl-1

Keywords: YM155; Akt; XIAP; Bcl-2; Mcl-1; AML;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Alpha2beta1 integrin promotes T cell survival and migration through the concomitant activation of ERK/Mcl-1 and p38 MAPK pathways

Keywords: T-ALL; T-cell acute lymphoblastic leukemia; ECM; Extracellular matrix; BMSCs; Bone marrow stromal cells; BSA; Bovine serum albumin; Collagen type I; Collagen; PLL; Poly-l-Lysine; Mcl-1; Myeloid cell leukemia 1; Bcl-2; B-cell lymphoma-2; Bcl-xL; B-cell lym

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1

Keywords: miR-125a-5p; Colon cancer; BCL2; BCL2L12; Mcl-1

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress

Keywords: Leukemia; BCR-ABL+; 2-deoxy-d-glucose; ER stress; Energy stress; UPR; Imatinib; Dasatinib; ERK; Mcl-1; AMPK; eIF2α; shRNA; Apoptosis; Tyrosine kinase inhibitors; Combination targeted therapy; Acute lymphoblastic leukemia;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Small molecule Mcl-1 inhibitors for the treatment of cancer

Keywords: Mcl-1; Myeloid cell leukemia-1; Inhibitors; Small molecule; BH3-mimetic; Bad; Bcl-2-associated death promoter; Bak; Bcl-2 homologous antagonist/killer; Bax; Bcl-2 associated X; Bcl-2; B-cell lymphoma-2; BH; Bcl-2 homology; BH3; Bcl-2 homology domain 3; Bc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors

Keywords: Apoptosis; Bcl-2; Mcl-1; Pyrrolidine; Anti-tumor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The FOXM1-induced resistance to oxaliplatin is partially mediated by its novel target gene Mcl-1 in gastric cancer cells

Keywords: FOXM1; Mcl-1; Apoptosis; Oxaliplatin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Baicalin inhibiting cerebral ischemia/hypoxia-induced neuronal apoptosis via MRTF-A-mediated transactivity

Keywords: Baicalin; MRTF-A; Neuronal apoptosis; MCL-1; BCL-2; PI3K; ERK1/2

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

BH3-only protein Bim is associated with the degree of Helicobacter pylori-induced gastritis and is localized to the mitochondria of inflammatory cells in the gastric mucosa

Keywords: BH3-only protein; Bim; Bcl-2; Bax; Apoptosis; Gastritis; Mitochondria; Helicobacter pyloriH. pylori, Helicobacter pylori; Bax, Bcl-2-associated X protein; Bak, Bcl-2 antagonistic killer; Bcl-2, B-cell lymphoma 2; Bcl-xL, B-cell lymphoma-extra large; Mcl-1

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

OVA12, a novel tumor antigen, promotes cancer cell growth and inhibits 5-fluorouracil-induced apoptosis

Keywords: OVA12; Tumor antigen; Tumorigenesis; 5-FU; Mcl-1; Survivin;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Mcl-1 antagonism is a potential therapeutic strategy in a subset of solid cancers

Keywords: Mcl-1; SiRNA; Apoptosis; Cancer; Mitochondria;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

NDRG2 promotes myoblast proliferation and caspase 3/7 activities during differentiation, and attenuates hydrogen peroxide - But not palmitate-induced toxicity

Keywords: NDRG2; N-myc downstream-regulated gene 2; MRFs; myogenic regulatory factors; Cdk; cyclin-dependent kinase; Rb; retinoblastoma; Myf5; myogenic factor 5; MyoD; myogenic differentiation; p27; p27 kip1; p21; p21 waf1/cip1; Akt; thymoma viral proto-oncogene; P

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Oncostatin M-dependent Mcl-1 induction mediated by JAK1/2-STAT1/3 and CREB contributes to bioenergetic improvements and protective effects against mitochondrial dysfunction in cortical neurons

Keywords: BH domain; Bcl-2 homology domain; CBP; CREB-binding protein; ChIP; chromatin immunoprecipitation; CHX; cycloheximide; CREB; cAMP-response element-binding protein; DIV; days-in-vitro; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FC

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein

Keywords: NMR; Fragment-based; FBDD; FBLD; Apoptosis; BCL; MCL-1;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Crizotinib (PF-2341066) induces apoptosis due to downregulation of pSTAT3 and BCL-2 family proteins in NPM-ALK+ anaplastic large cell lymphoma

Keywords: Crizotinib; STAT3; ALCL; NPM-ALK; MCL-1;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

The VTLISFG motif in the BH1 domain plays a significant role in regulating the degradation of Mcl-1

Keywords: Apoptosis; Mcl-1; Degradation motif; PEST domain; β-TrCP; β-transducin repeat-containing protein; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma-2; BH domain; Bcl-2 homology domain; Bim; Bcl-2-interacting mediator; BSA; bovine serum albumin; Ca

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

p32, a novel binding partner of Mcl-1, positively regulates mitochondrial Ca2+ uptake and apoptosis

Keywords: Co-IP; co-immunoprecipitation; DMSO; dimethyl sulfoxide; GFP; green fluorescent protein; RuRed; Ruthenium Red; YFP; yellow fluorescent protein; Y2H; Yeast Two Hybrid; Apoptosis; Mcl-1; p32; Mitochondria; Calcium; Mitochondrial calcium uniporter;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

MCL-1 dependency of cisplatin-resistant cancer cells

Keywords: MCL-1; Chemoresistance; Obatoclax; PARP1; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

MicroRNA-363-mediated downregulation of S1PR1 suppresses the proliferation of hepatocellular carcinoma cells

Keywords: S1PR1; sphingosine-1-phosphate receptor-1; miRs; microRNAs; SphK1; sphingosine kinases 1; S1P; sphingosine 1-phosphate; ERK; extracellular signal-regulated kinase; STAT3; signal transducers and activators of transcription 3; PDGF-A; platelet derived growt

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2

Keywords: Dual inhibitors; Hydrogen bond; Apoptosis; Mcl-1; Bcl-2;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

BAG3 upregulates Mcl-1 through downregulation of miR-29b to induce anticancer drug resistance in ovarian cancer

Keywords: BAG3; Mcl-1; miR-29b; Ovarian cancer; Chemoresistance;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Research ArticleMicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity

Keywords: EZH2; enhancer of zeste homolog 2; miR-101; microRNA-101; HCC; hepatocellular carcinoma; miRNA(s); microRNA(s); mRNA(s); messenger RNA(s); Mcl-1; myeloid cell leukemia sequence 1; siRNAs; small interfering RNAs; qPCR; quantitative real-time PCR; UTR; untr

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Targeting Mcl-1 for multiple myeloma (MM) therapy: Drug-induced generation of Mcl-1 fragment Mcl-1128-350 triggers MM cell death via c-Jun upregulation

Keywords: Mcl-1; c-Jun; Multiple myeloma; Apoptosis; MEFs; Glioblastoma;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Gö6976, a FLT3 kinase inhibitor, exerts potent cytotoxic activity against acute leukemia via inhibition of survivin and MCL-1

Keywords: Apoptosis; Gö6976; STAT3; MCL-1; Survivin; FLT3 inhibitor

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Imperatorin induces Mcl-1 degradation to cooperatively trigger Bax translocation and Bak activation to suppress drug-resistant human hepatoma

Keywords: Imperatorin; Drug-resistant HepG2 cells; Mcl-1; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه