کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8259110 | 1534630 | 2016 | 48 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice
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کلمات کلیدی
ALTBcl-xLMCDα-SMACCR2SOD1GSRC-C chemokine receptor type 2IL-1βPDGFRANASPDGFRBCCl4MCP-1HGFPGE2pdgfaNAFLDIL-6TGF-β1Methionine and choline deficient dietB-cell lymphoma-extra-largeCATCollagen type I alpha 1DFURCDCOX-2Ly6CMcl-1pdgfbCOL1A1alanine transaminase - آلانین ترانس آمینازalpha smooth muscle actin - آلفا آکتیو عضله صافNon-alcoholic steatohepatitis - استئاتوهپاتیت غیرالکلیSteatohepatitis - استاتو هپاتیتinflammation - التهاب( توروم) interleukin 1β - اینترلوکین 1βinterleukin 6 - اینترلوکین 6Bax - باکسnon-alcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیTransforming growth factor β1 - تبدیل فاکتور رشد β1Triglycerides - تریگلیسریدtumor necrosis factor α - تومور نکروز عامل αsuperoxide dismutase 1 - سوپر اکسید دیسموتاز 1Superoxide dismutase 2 - سوکسوکس دیسموتاز 2Cyclooxygenase-2 - سیکلوکوکسیژناز2Hepatocyte growth factor - عامل رشد هپاتوسیتTNF-α - فاکتور نکروز توموری آلفاFibrosis - فیبروز یا فساد الیافMyeloid cell leukemia 1 - لوسمی سلول میلوئید 1Nash - نوشMonocyte chemotactic protein-1 - پروتئین chemotactic monocyte-1Bcl-2-associated X protein - پروتئین X مرتبط با Bcl-2Prostaglandin E2 - پروستاگلاندین E2platelet-derived growth factor receptor beta - پلاکت عامل گیرنده بتای فاکتور رشدCatalase - کاتالازLiver - کبدNormal liver - کبد طبیعیCarbon tetrachloride - کربن تتراکلریدglutathione reductase - گلوتاتیون ردوکتازPlatelet-derived growth factor receptor alpha - گیرنده آلفای فاکتور رشد حاصل از پلاکت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice](/preview/png/8259110.png)
چکیده انگلیسی
Cyclooxygenase-2 (COX-2) is involved in different liver diseases but little is known about the significance of COX-2 in the development and progression of non-alcoholic steatohepatitis (NASH). This study was designed to elucidate the role of COX-2 expression in hepatocytes in the pathogenesis of steatohepatitis and hepatic fibrosis. In the present work, hepatocyte-specific COX-2 transgenic mice (hCOX-2-Tg) and their wild-type (Wt) littermates were either fed methionine-and-choline deficient (MCD) diet to establish an experimental non-alcoholic steatohepatitis (NASH) model or injected with carbon tetrachloride (CCl4) to induce liver fibrosis. In our animal model, hCOX-2-Tg mice fed MCD diet showed lower grades of steatosis, ballooning and inflammation than Wt mice, in part by reduced recruitment and infiltration of hepatic macrophages, with a corresponding decrease in serum levels of pro-inflammatory cytokines. Furthermore, hCOX-2-Tg mice showed a significant attenuation of the MCD diet-induced increase in oxidative stress and hepatic apoptosis observed in Wt mice. Even more, hCOX-2-Tg mice treated with CCl4 had significantly lower stages of fibrosis and less hepatic content of collagen, hydroxyproline and pro-fibrogenic markers than Wt controls. Collectively, our data indicates that constitutive hepatocyte COX-2 expression ameliorates NASH and liver fibrosis development in mice by reducing inflammation, oxidative stress and apoptosis and by modulating activation of hepatic stellate cells, respectively, suggesting a possible protective role for COX-2 induction in NASH/NAFLD progression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1862, Issue 9, September 2016, Pages 1710-1723
Journal: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease - Volume 1862, Issue 9, September 2016, Pages 1710-1723
نویسندگان
Omar Motiño, Noelia Agra, RocÃo Brea Contreras, Marina DomÃnguez-Moreno, Carmelo GarcÃa-Monzón, Javier Vargas-Castrillón, Cristina E. Carnovale, Lisardo Boscá, Marta Casado, Rafael Mayoral, M. Pilar Valdecantos, Ángela M. Valverde,