کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138431 1087876 2009 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Significance of four MRD markers in MRD-based treatment strategy for childhood acute lymphoblastic leukemia
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Significance of four MRD markers in MRD-based treatment strategy for childhood acute lymphoblastic leukemia
چکیده انگلیسی

Newly diagnosed children with ALL (n = 32) were treated on a protocol incorporating minimal residual disease (MRD)-based treatment decisions. MRD was monitored at 4 time points by semi-quantitative PCR detection of antigen receptor gene rearrangement, flow cytometry, quantitative RT-PCR detection of chimeric gene transcripts and overexpressed WT1 mRNA. Four patients positive for MRD at week 5 were treated with an intensified regimen. Median follow-up was 5.0 years (range 3.8–6.6 years) with a 4-year event-free survival rate of 93.8 ± 4.3%. This MRD-based treatment strategy seems to be highly successful and may improve the outcomes of children with ALL. A large study is warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 33, Issue 12, December 2009, Pages 1710–1713
نویسندگان
, , , , , , , , , , , ,