کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2138431 | 1087876 | 2009 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Significance of four MRD markers in MRD-based treatment strategy for childhood acute lymphoblastic leukemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Newly diagnosed children with ALL (n = 32) were treated on a protocol incorporating minimal residual disease (MRD)-based treatment decisions. MRD was monitored at 4 time points by semi-quantitative PCR detection of antigen receptor gene rearrangement, flow cytometry, quantitative RT-PCR detection of chimeric gene transcripts and overexpressed WT1 mRNA. Four patients positive for MRD at week 5 were treated with an intensified regimen. Median follow-up was 5.0 years (range 3.8–6.6 years) with a 4-year event-free survival rate of 93.8 ± 4.3%. This MRD-based treatment strategy seems to be highly successful and may improve the outcomes of children with ALL. A large study is warranted.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 33, Issue 12, December 2009, Pages 1710–1713
Journal: Leukemia Research - Volume 33, Issue 12, December 2009, Pages 1710–1713
نویسندگان
Akihisa Sawada, Naoki Sakata, Tomoko Kishimoto, Banryoku Higuchi, Maho Koyama, Osamu Kondo, Emiko Sato, Takayuki Okamura, Masahiro Yasui, Masami Inoue, Akira Yoshioka, Keisei Kawa,