کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2138776 1087885 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synergistic effects of troglitazone in combination with cytotoxic agents in acute myelogenous leukaemia cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Synergistic effects of troglitazone in combination with cytotoxic agents in acute myelogenous leukaemia cells
چکیده انگلیسی

We have previously shown that troglitazone (TG) induces apoptosis in acute myelogenous leukaemia (AML) cell lines. Here we show that normal bone marrow and mobilized peripheral blood progenitors are highly resistant to TG at concentrations up to 100 μM, while primary cultures of AML bone marrow show significant decline in viability at >7.5 μM TG. The combination of standard cytotoxic agents (daunorubicin, etoposide, and cytarabine) with TG is synergistic in six AML cell lines, with the strongest synergy being exhibited when cells are pretreated with TG for 24 h prior to addition of the cytotoxic agent. Significant declines in IC50 for the cytotoxic agents are seen at nanomolar concentrations of TG. The in vitro synergy between TG and the cytotoxic drugs used in AML therapy provides a basis for in vivo evaluation of these combinations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 30, Issue 11, November 2006, Pages 1447–1451
نویسندگان
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