کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2138996 | 1087892 | 2006 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Aven overexpression: Association with poor prognosis in childhood acute lymphoblastic leukemia
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
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چکیده انگلیسی
Aven expression has recently been identified as an anti-apoptotic protein. In this study, Aven expression in 91 children with acute lymphoblastic leukemia (ALL) was investigated for possible correlation with clinical features at diagnosis and treatment outcome. Aven expression was found to be higher in patients ≥10 years old or <1 year (P = 0.003), and in patients with unfavorable cytogenetic abnormalities (P < 0.001). Aven expression was also significantly higher in relapsed patients in the standard-risk group. Aven overexpression was an independent poor prognostic factor. These findings demonstrate that Aven expression can predict prognosis in childhood ALL.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 30, Issue 8, August 2006, Pages 1019–1025
Journal: Leukemia Research - Volume 30, Issue 8, August 2006, Pages 1019–1025
نویسندگان
Jaewon Choi, Yu Kyeong Hwang, Ki Woong Sung, Dong Hyun Kim, Keon Hee Yoo, Hye Lim Jung, Hong Hoe Koo,