کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2139587 1087911 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Dequalinium induces cell death in human leukemia cells by early mitochondrial alterations which enhance ROS production
چکیده انگلیسی
Dequalinium (DQA) has been proposed as a selective antitumoral agent due to its preferential accumulation in mitochondria of cancer cells. Our aim was a better understanding of DQA cytotoxicity. DQA-induced NB4 and K562 cell alterations are initiated within the first 30 min of treatment at a high DQA concentration with a mitochondrial membrane depolarization. Cytochrome c release to cytoplasm, superoxide anion overproduction and ATP depletion in NB4 cells induce, 16 h later, apoptosis by a typical caspase-9/caspase-3-dependent intrinsic pathway. K562 cells were more resistant to the DQA effect than NB4 cells, remaining viable for longer time periods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Leukemia Research - Volume 31, Issue 7, July 2007, Pages 969-978
نویسندگان
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