کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2144792 | 1548019 | 2014 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: R-spondins: Novel matricellular regulators of the skeleton R-spondins: Novel matricellular regulators of the skeleton](/preview/png/2144792.png)
• R-spondins are a unique family of matricellular proteins.
• R-spondins contain a single TSR1 domain and two furin repeats.
• R-spondins regulate canonical Wnt-signaling.
• R-spondins stabilize Wnt receptors by inhibiting receptor turnover.
• R-spondins play roles in tissue morphogenesis and particularly regulate skeletal development and bone formation.
R-spondins are a family of four matricellular proteins produced by a variety of cell-types. Structurally, R-spondins contain a TSR1 domain that retains the tryptophan structure and a modified cysteine-rich CSVCTG region. In addition, the R-spondins contain two furin repeats implicated in canonical Wnt signaling. R-spondins positively regulate canonical Wnt signaling by reducing Wnt receptor turnover and thereby increasing beta-catenin stabilization. R-spondins are prominently expressed in the developing skeleton and contribute to limb formation, particularly of the distal digit. Additionally, results suggest that R-spondins may contribute to the maintenance of adult bone mass by regulating osteoblastogenesis and bone formation.
Journal: Matrix Biology - Volume 37, July 2014, Pages 157–161