Granzyme B cleavage of fibronectin disrupts endothelial cell adhesion, migration and capillary tube formation

► Granzyme B generates multiple soluble fibronectin fragments from both plasma-derived and cell-derived fibronectin. ► Fibronectin proteolysis by granzyme B reduces endothelial cell adhesion and migration. ► Granzyme B disrupts capillary tube formation in 3D collagen gels. ► Using a small molecule granzyme B inhibitor restores the physiologic angiogenic potential of endothelial cells.