Inhibitory effect of Survivin promoter-regulated oncolytic adenovirus carrying P53 gene against gallbladder cancer

▶ Survivin promoter-regulated oncolytic adenovirus AdSurp-P53 is recombined. ▶ The oncolytic adenovirus has a high proliferation activity in gallbladder cancer. ▶ The oncolytic adenovirus mediates high P53 expression in gallbladder cancer cells. ▶ AdSurp-P53 possesses a stronger cytotoxic effect against gallbladder cancer cells. ▶ AdSurp-P53 inhibits xenograft tumor growth in nude mice by inducing cell apoptosis.