Are two better than one? A novel double-mutant KIT in GIST that responds to Imatinib

► Two mutations, one novel, in KIT exon 11 were identified in one GIST patient. ► KIT exon 11 PCR fragment subcloning showed the mutations were on the same allele. ► KIT receptor carries the two corresponding aminoacidic substitutions. ► Biochemical/in silico analyses showed double KIT mutant is Imatinib sensitive. ► The patient, Imatinib treated, continues to respond well to the therapy.