Centrosome clustering and chromosomal (in)stability: A matter of life and death

► Centrosome abnormalities occur commonly in cancer. ► Centrosome clustering enables cells with extra centrosomes to divide successfully. ► We discuss the molecular basis of centrosome clustering and its biological roles. ► Clustering impacts on stem cell division, chromosomal stability and tumorigenesis. ► Inhibition of centrosome clustering promises to selectively target tumor cells.