کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2145994 1088843 2011 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chromatin and the DNA damage response: The cancer connection
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Chromatin and the DNA damage response: The cancer connection
چکیده انگلیسی

The integrity of the human genome is constantly threatened by genotoxic agents that cause DNA damage. Inefficient or inaccurate repair of DNA lesions triggers genome instability and can lead to cancer development or even cell death. Cells counteract the adverse effects of DNA lesions by activating the DNA damage response (DDR), which entails a coordinated series of events that regulates cell cycle progression and repair of DNA lesions. Efficient DNA repair in living cells is complicated by the packaging of genomic DNA into a condensed, often inaccessible structure called chromatin. Cells utilize post-translational histone modifications and ATP-dependent chromatin remodeling to modulate chromatin structure and increase the accessibility of the repair machinery to lesions embedded in chromatin. Here we review and discuss our current knowledge and recent advances on DNA damage-induced chromatin changes and their implications for the mammalian DNA damage response, genome stability and carcinogenesis. Exploiting our improving understanding of how modulators of chromatin structure orchestrate the DDR may provide new avenues to improve cancer management.


► Efficient DNA repair is complicated by the packaging of genomic DNA into chromatin.
► Chromatin structure is modulated by histone modification and chromatin remodeling.
► Chromatin modifying enzymes increase the accessibility of DNA lesions in chromatin.
► DNA damage-induced chromatin changes promote DNA repair and genomic stability.
► Targeting chromatin modifying enzymes may provide new avenues for cancer therapies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 5, Issue 4, August 2011, Pages 349–367
نویسندگان
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