کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2148294 | 1089551 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cellular radioprotecting potential of glyzyrrhizic acid, silver nanoparticle and their complex
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cellular radioprotecting potential of glyzyrrhizic acid, silver nanoparticle and their complex Cellular radioprotecting potential of glyzyrrhizic acid, silver nanoparticle and their complex](/preview/png/2148294.png)
چکیده انگلیسی
Silver nanoparticles (SN) of particle size of less than 50Â nm were redispersed in aqueous solution of Pluronic F127 and complexed with the phytoceutical, glyzyrrhizic acid (GLY). Radioprotecting ability of the obtained nanoparticle-glyzyrrhizic acid complex (SN-GLY) was evaluated in an in vivo model using Swiss albino mice. Oral administration of SN-GLY, SN and GLY one hour prior to radiation exposure reduced the radiation induced damage in peripheral blood leucocytes, bone marrow cells and spleen cells of mice as revealed by comet assay. Exposure of mice to whole body gamma irradiation resulted in formation of micronuclei in blood reticulocytes and chromosomal aberrations in bone marrow cells while SN-GLY, SN or GLY administration resulted in reduction in micronucleus formation and chromosomal aberrations indicating radioprotection. In SN-GLY treated mice the cellular DNA was found protected to a greater extent compared to GLY or SN treated mice. The studies, under in vivo radiation exposure conditions, showed effective radiation protection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 723, Issue 1, 14 July 2011, Pages 51-57
Journal: Mutation Research/Genetic Toxicology and Environmental Mutagenesis - Volume 723, Issue 1, 14 July 2011, Pages 51-57
نویسندگان
Dhanya K. Chandrasekharan, Pawan K. Khanna, Cherupally Krishnan Krishnan Nair,