کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2151267 | 1089977 | 2014 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
FLI1 Expression is Correlated with Breast Cancer Cellular Growth, Migration, and Invasion and Altered Gene Expression
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کلمات کلیدی
PDEFFli1normal breast tissueuPAILCGEOGAPDHIDCIHC - ایمونوهیستوشیمیImmunohistochemistry - ایمونوهیستوشیمیTumor - تومورEMT - تکنسین فوریتهای پزشکیretinoblastoma - رتینوبلاستوما، تومور شبکیهurokinase plasminogen activator - فعال کننده پلاسمینوژن یوروکینازGene Expression Omnibus - ژن بیان OmnibusInvasive lobular carcinoma - کارسینوم لوبولار مهاجمInvasive ductal carcinoma - کارسینوم مجرای تهاجمیEpithelial-mesenchymal transition - گذار اپیتلیال-مزانشیمیglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژنازEstrogen receptor - گیرنده استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: FLI1 Expression is Correlated with Breast Cancer Cellular Growth, Migration, and Invasion and Altered Gene Expression FLI1 Expression is Correlated with Breast Cancer Cellular Growth, Migration, and Invasion and Altered Gene Expression](/preview/png/2151267.png)
چکیده انگلیسی
ETS factors have been shown to be dysregulated in breast cancer. ETS factors control the expression of genes involved in many biological processes, such as cellular proliferation, differentiation, and apoptosis. FLI1 is an ETS protein aberrantly expressed in retrovirus-induced hematological tumors, but limited attention has been directed towards elucidating the role of FLI1 in epithelial-derived cancers. Using data mining, we show that loss of FLI1 expression is associated with shorter survival and more aggressive phenotypes of breast cancer. Gain and loss of function cellular studies indicate the inhibitory effect of FLI1 expression on cellular growth, migration, and invasion. Using Fli1 mutant mice and both a transgenic murine breast cancer model and an orthotopic injection of syngeneic tumor cells indicates that reduced Fli1 contributes to accelerated tumor growth. Global expression analysis and RNA-Seq data from an invasive human breast cancer cell line with over expression of either FLI1 and another ETS gene, PDEF, shows changes in several cellular pathways associated with cancer, such as the cytokine-cytokine receptor interaction and PI3K-Akt signaling pathways. This study demonstrates a novel role for FLI1 in epithelial cells. In addition, these results reveal that FLI1 down-regulation in breast cancer may promote tumor progression.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neoplasia - Volume 16, Issue 10, October 2014, Pages 801-813
Journal: Neoplasia - Volume 16, Issue 10, October 2014, Pages 801-813
نویسندگان
Melissa N. Scheiber, Patricia M. Watson, Tihana Rumboldt, Connor Stanley, Robert C. Wilson, Victoria J. Findlay, Paul E. Anderson, Dennis K. Watson,