کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2151357 | 1089985 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genome-wide Association Study Identifies Genetic Determinants of Urine PCA3 Levels in Men
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کلمات کلیدی
PSAPCA3IPSSReduction by Dutasteride of Prostate Cancer EventsKLK3PCA - PCAβ-microseminoprotein - β-میکروسیمینوپروتئینProstate cancer - سرطان پروستاتGenome-wide association study - مطالعه مرتبط با ژنومGWAS - مطالعهٔ همخوانی سراسر ژنومInternational Prostate Symptom Score - نمره علائم بین المللی پروستاتprostate-specific antigen - پادگن مخصوص پروستاتprostate cancer gene 3 - ژن 3 سرطان پروستاتreduce - کاستن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Prostate cancer gene 3 (PCA3) is a non-coding gene specifically overexpressed in prostate cancer (PCa) that has great potential as a clinical biomarker for predicting prostate biopsy outcome. However, genetic determinants of PCA3 expression level remain unknown. To investigate the association between genetic variants and PCA3 mRNA level, a genome-wide association study was conducted in 1371 men of European descent in the REduction by DUtasteride of prostate Cancer Events trial. First-voided urine specimens containing prostate cells were obtained after digital rectal examination. The PROGENSA PCA3 assay was used to determine PCA3 score in the urinary samples. A linear regression model was used to detect the associations between (single nucleotide polymorphisms) SNPs and PCA3 score under an additive genetic model, adjusting for age and population stratification. Two SNPs, rs10993994 in β-microseminoprotein at 10q11.23 and rs10424878 in kallikrein-related peptidase 2 at 19q13.33, were associated with PCA3 score at genome-wide significance level (P = 1.22 x 10-9 and 1.06 x 10-8, respectively). Men carrying the rs10993994 “T” allele or rs10424878 “A” allele had higher PCA3 score compared with men carrying rs10993994 “C” allele or rs10424878 “G” allele (β = 1.25 and 1.24, respectively). This is the first comprehensive search for genetic determinants of PCA3 score. The novel loci identified may provide insight into the molecular mechanisms of PCA3 expression as a potential marker of PCa.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neoplasia - Volume 15, Issue 4, April 2013, Pages 448-453, IN23-IN26
Journal: Neoplasia - Volume 15, Issue 4, April 2013, Pages 448-453, IN23-IN26
نویسندگان
Zhuo Chen, Jielin Sun, Seong-Tae Kim, Jack Groskopf, Junjie Feng, William B. Isaacs, Roger S. Rittmaster, Lynn D. Condreay, Siqun Lilly Zheng, Jianfeng Xu,