کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2151506 | 1089998 | 2012 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Statins Impair Glucose Uptake in Tumor Cells
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کلمات کلیدی
GLUT2-DOG2-DeoxyglucosePBMCCRACMβCD18F-FDGFPPPET/CT - PET / CTMevalonic acid - اسید Mevaloniccholesterol recognition/interaction amino acid consensus - تشخیص کلسترول / تعامل آمینو اسیدpositron emission tomography/computed tomography - توموگرافی انتشارات Positron / توموگرافی کامپیوتریGlucose transporter - حمل و نقل گلوکزcluster of differentiation - خوشه تمایزPeripheral blood mononuclear cell - سلول تک هسته ای خون محیطیfarnesyl pyrophosphate - فارسیل پیرو فسفاتSUV - ماشین شاسی بلندmethyl-β-cyclodextrin - متیل-β-سیکلوکودکسترینstandardized uptake value - مقدار جذب استاندارد شدهhemagglutinin - هماگلوتینین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Statins, HMG-CoA reductase inhibitors, are used in the prevention and treatment of cardiovascular diseases owing to their lipid-lowering effects. Previous studies revealed that, by modulating membrane cholesterol content, statins could induce conformational changes in cluster of differentiation 20 (CD20) tetraspanin. The aim of the presented study was to investigate the influence of statins on glucose transporter 1 (GLUT1)-mediated glucose uptake in tumor cells. We observed a significant concentration- and time-dependent decrease in glucose analogs' uptake in several tumor cell lines incubated with statins. This effect was reversible with restitution of cholesterol synthesis pathway with mevalonic acid as well as with supplementation of plasma membrane with exogenous cholesterol. Statins did not change overall GLUT1 expression at neither transcriptional nor protein levels. An exploratory clinical trial revealed that statin treatment decreased glucose uptake in peripheral blood leukocytes and lowered 18F-fluorodeoxyglucose (18F-FDG) uptake by tumor masses in a mantle cell lymphoma patient. A bioinformatics analysis was used to predict the structure of human GLUT1 and to identify putative cholesterol-binding motifs in its juxtamembrane fragment. Altogether, the influence of statins on glucose uptake seems to be of clinical significance. By inhibiting 18F-FDG uptake, statins can negatively affect the sensitivity of positron emission tomography, a diagnostic procedure frequently used in oncology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neoplasia - Volume 14, Issue 4, April 2012, Pages 311-323
Journal: Neoplasia - Volume 14, Issue 4, April 2012, Pages 311-323
نویسندگان
Agata Malenda, Anna Skrobanska, Tadeusz Issat, Magdalena Winiarska, Jacek Bil, Bozenna Oleszczak, Maciej Sinski, MaÅgorzata Firczuk, Janusz M. Bujnicki, Justyna Chlebowska, Adam D. Staruch, Eliza Glodkowska-Mrowka, Jolanta Kunikowska, Leszek Krolicki,