کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2159277 1090854 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An in vivo investigative protocol for HDR prostate brachytherapy using urethral and rectal thermoluminescence dosimetry
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
An in vivo investigative protocol for HDR prostate brachytherapy using urethral and rectal thermoluminescence dosimetry
چکیده انگلیسی

PurposeTo develop an in vivo dosimetry based investigative action level relevant for a corrective protocol for HDR brachytherapy boost treatment.Methods and materialsThe dose delivered to points within the urethra and rectum was measured using TLD in vivo dosimetry in 56 patients. Comparisons between the urethral and rectal measurements and TPS calculations showed differences, which are related to the relative position of the implant and TLD trains, and allowed shifts of implant position relative to the prostate to be estimated.Results and conclusionsAnalysis of rectal dose measurements is consistent with implant movement, which was previously only identified with the urethral data. Shift corrected doses were compared with results from the TPS. Comparison of peak doses to the urethra and rectum has been assessed against the proposed corrective protocol to limit overdosing these critical structures. An initial investigative level of 20% difference between measured and TPS peak dose was established, which corresponds to 1/3 of patients which was practical for the caseload. These patients were assessed resulting in corrective action being applied for one patient. Multiple triggering for selective investigative action is outlined. The use of a single in vivo measurement in the first fraction optimizes patient benefit at acceptable cost.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 91, Issue 2, May 2009, Pages 243–248
نویسندگان
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