کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2166154 | 1091823 | 2011 | 11 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Calcium and cell death mechanisms: A perspective from the cell death community Calcium and cell death mechanisms: A perspective from the cell death community](/preview/png/2166154.png)
Research during the past several decades has provided convincing evidence for a crucial role of the Ca2+ ion in cell signaling. Hence, intracellular Ca2+ transients have been implicated in most aspects of cell physiology, including gene transcription, cell cycle regulation and cell proliferation. Further, the Ca2+ ion has been found to also play an important role in cell death regulation. Thus, necrotic cell death was early associated with intracellular Ca2+ overload, and multiple functions in the apoptotic process have subsequently been found to be governed by Ca2+ signaling. More recently, other modes of cell death, notably anoikis and autophagic cell death, have been demonstrated to also be modulated by Ca2+ transients. Characteristics, interrelationship and mechanisms involved in Ca2+ regulation of these cell death modalities are discussed in this review.
Journal: Cell Calcium - Volume 50, Issue 3, September 2011, Pages 211–221