کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2166491 1549325 2007 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Primary structure, chromosomal localization and expression in immune cells of the murine ORAI and STIM genes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Primary structure, chromosomal localization and expression in immune cells of the murine ORAI and STIM genes
چکیده انگلیسی
Recently ORAI and STIM proteins were identified as components of the CRAC channel and the endoplasmic reticulum Ca2+ sensor, respectively. The ORAI proteins share a predicted structure that includes four transmembrane domains with intracellular N- and C-termini. They share structural similarity with proteins of the tetraspanin superfamily which includes the gamma subunits of voltage-activated Ca2+ channels (CaVγ), the transmembrane AMPA regulatory proteins (TARPs), the claudins and the tumor-associated membrane proteins (TMPs). The mouse genome contains four genes which encode the ORAI1, ORAI2 and ORAI3 proteins and two genes which encode the type I single-pass transmembrane STIM1 and STIM2 proteins. ORAI2 transcripts are present in primary cortical neurons and ORAI1, 2, 3 and STIM1, 2 expression is readily detectable in CD3+/CD4+-, CD3+/CD8+-, and CD19+-lymphocytes as well as in mast cells from mouse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Calcium - Volume 42, Issues 4–5, October–November 2007, Pages 439-446
نویسندگان
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