کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2166491 | 1549325 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Primary structure, chromosomal localization and expression in immune cells of the murine ORAI and STIM genes
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Recently ORAI and STIM proteins were identified as components of the CRAC channel and the endoplasmic reticulum Ca2+ sensor, respectively. The ORAI proteins share a predicted structure that includes four transmembrane domains with intracellular N- and C-termini. They share structural similarity with proteins of the tetraspanin superfamily which includes the gamma subunits of voltage-activated Ca2+ channels (CaVγ), the transmembrane AMPA regulatory proteins (TARPs), the claudins and the tumor-associated membrane proteins (TMPs). The mouse genome contains four genes which encode the ORAI1, ORAI2 and ORAI3 proteins and two genes which encode the type I single-pass transmembrane STIM1 and STIM2 proteins. ORAI2 transcripts are present in primary cortical neurons and ORAI1, 2, 3 and STIM1, 2 expression is readily detectable in CD3+/CD4+-, CD3+/CD8+-, and CD19+-lymphocytes as well as in mast cells from mouse.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Calcium - Volume 42, Issues 4â5, OctoberâNovember 2007, Pages 439-446
Journal: Cell Calcium - Volume 42, Issues 4â5, OctoberâNovember 2007, Pages 439-446
نویسندگان
Ulrich Wissenbach, Stephan Ernst Philipp, Stefan Alfred Gross, Adolfo Cavalié, Veit Flockerzi,